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Table 2 Annotation of proteins which were significantly altered in ccRCC as compared to norml tissue.

From: Pathway analysis of kidney cancer using proteomics and metabolic profiling

Symbol Gene Entrez Gene ID Biological Process Molecular Function Associated Cancer
ACY1 aminoacylase 1 95 Amino acid biosynthesis Hydrolase;Metalloprotease  
ASS argininosuccinate synthetase 445 Amino acid biosynthesis;Nitrogen metabolism Ligase liver cancer
AGMAT agmatine ureohydrolase (agmatinase) 79814 Amino acid catabolism Hydrolase  
BHMT betaine-homocysteine methyltransferase 635 Amino acid metabolism Methyltransferase  
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase) 2628 Amino acid metabolism Transferase  
CLIC1 chloride intracellular channel 1 1192 Anion transport;Other homeostasis activities Anion channel breast and ovarian cancers
PRDX1 peroxiredoxin 1 5052 Antioxidation and free radical removal Peroxidase breast, liver and pancreatic cancers
GSTO2 glutathione-S-transferase, alpha-class, omega 2 subunit 119391 Detoxification;Antioxidation and free radical removal Transferase ovarian cancer
ECHS1 enoyl Coenzyme A hydratase, short chain, 1, mitochondrial 1892 Carbohydrate metabolism;Fatty acid beta-oxidation;Coenzyme metabolism;Vitamin biosynthesis Synthetase;Dehydrogenase;Acetyltransferase;Acyltransferase;Hydratase;Epimerase/racemase;Ligase liver cancer
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 5106 Gluconeogenesis Decarboxylase liver cancer
AKR1A1 aldo-keto reductase family 1, member A1 (aldehyde reductase 2ALR) 10327 Glucose metabolism; aldehyde metabolism Reductase breast cancer
ALDOB aldolase B, fructose-bisphosphate 229 Glycolysis Aldolase liver cancer
ENO2 enolase 2, (gamma, neuronal) 2026 Glycolysis Lyase breast, lung and prostate cancers
GAPDH glyceraldehyde-3-phosphate dehydrogenase 2597 Glycolysis Oxidoreductase liver, lung and ovarian cancers
LDHA lactate dehydrogenase A 3939 Glycolysis Dehydrogenase breast and ovarian cancers
PKM2 pyruvate kinase, muscle 5315 Glycolysis Carbohydrate kinase ovarian cancer
SUCLG1 succinate-CoA ligase, GDP-forming, alpha subunit 8802 Tricarboxylic acid pathway Synthetase breast cancer
FABP7 fatty acid binding protein 7, brain 2173 Lipid and fatty acid transport;Lipid and fatty acid binding; Vitamin/cofactor transport;Steroid hormone-mediated signaling;Transport;Ectoderm development Transfer/carrier protein breast cancer
ANXA4 annexin A4 307 Lipid, fatty acid and steroid metabolism Transfer/carrier protein;Annexin pancreatic cancer
ANXA5 Annexin V 308 Lipid, fatty acid and steroid metabolism Transfer/carrier protein;Annexin breast and pancreatic cancers
ACAT1 acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase) 38 Protein acetylation Acetyltransferase liver cancer
HSPD1 heat shock 60kDa protein 1 (chaperonin) 3329 Protein folding;Protein complex assembly Chaperonin lung cancer
HSPB1 heat shock 27kDa protein 1 3315 Protein folding;Stress response Chaperones Colon, breast, ovarian cancer and pancreatic cancers
HSPCB heat shock 90kDa protein 1, beta 3326 Protein folding;Stress response Hsp 90 family chaperone  
CSTB cystatin B (stefin B) 1476 Proteolysis Cysteine protease inhibitor prostate cancer
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) 5721 Proteolysis Miscellaneous function protein breast cancer
CALB1 calbindin 1, 28kDa 793 Calcium mediated signaling;Calcium ion homeostasis Select calcium binding protein  
TBB2 tubulin, beta polypeptide 7280 Intracellular protein traffic;Chromosome segregation;Cell structure;Cell motility Protein polymerization breast cancer
ATP5D ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit 513 Nucleoside, nucleotide and nucleic acid metabolism;Electron transport;Cation transport Hydrogen transporter;Synthase;Other hydrolase lung cancer
ATP5H ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d 10476 ATP synthesis coupled proton transport ATP synthase lung and ovarian cancer
HINT1 histidine triad nucleotide binding protein 1 (PKCi substrate analog) 3094 Signal transduction Nucleotide phosphatase breast cancer