Table 2 Annotation of proteins which were significantly altered in ccRCC as compared to norml tissue.
From: Pathway analysis of kidney cancer using proteomics and metabolic profiling
Symbol | Gene | Entrez Gene ID | Biological Process | Molecular Function | Associated Cancer |
|---|---|---|---|---|---|
ACY1 | aminoacylase 1 | 95 | Amino acid biosynthesis | Hydrolase;Metalloprotease | |
ASS | argininosuccinate synthetase | 445 | Amino acid biosynthesis;Nitrogen metabolism | Ligase | liver cancer |
AGMAT | agmatine ureohydrolase (agmatinase) | 79814 | Amino acid catabolism | Hydrolase | |
BHMT | betaine-homocysteine methyltransferase | 635 | Amino acid metabolism | Methyltransferase | |
GATM | glycine amidinotransferase (L-arginine:glycine amidinotransferase) | 2628 | Amino acid metabolism | Transferase | |
CLIC1 | chloride intracellular channel 1 | 1192 | Anion transport;Other homeostasis activities | Anion channel | breast and ovarian cancers |
PRDX1 | peroxiredoxin 1 | 5052 | Antioxidation and free radical removal | Peroxidase | breast, liver and pancreatic cancers |
GSTO2 | glutathione-S-transferase, alpha-class, omega 2 subunit | 119391 | Detoxification;Antioxidation and free radical removal | Transferase | ovarian cancer |
ECHS1 | enoyl Coenzyme A hydratase, short chain, 1, mitochondrial | 1892 | Carbohydrate metabolism;Fatty acid beta-oxidation;Coenzyme metabolism;Vitamin biosynthesis | Synthetase;Dehydrogenase;Acetyltransferase;Acyltransferase;Hydratase;Epimerase/racemase;Ligase | liver cancer |
PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | 5106 | Gluconeogenesis | Decarboxylase | liver cancer |
AKR1A1 | aldo-keto reductase family 1, member A1 (aldehyde reductase 2ALR) | 10327 | Glucose metabolism; aldehyde metabolism | Reductase | breast cancer |
ALDOB | aldolase B, fructose-bisphosphate | 229 | Glycolysis | Aldolase | liver cancer |
ENO2 | enolase 2, (gamma, neuronal) | 2026 | Glycolysis | Lyase | breast, lung and prostate cancers |
GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 2597 | Glycolysis | Oxidoreductase | liver, lung and ovarian cancers |
LDHA | lactate dehydrogenase A | 3939 | Glycolysis | Dehydrogenase | breast and ovarian cancers |
PKM2 | pyruvate kinase, muscle | 5315 | Glycolysis | Carbohydrate kinase | ovarian cancer |
SUCLG1 | succinate-CoA ligase, GDP-forming, alpha subunit | 8802 | Tricarboxylic acid pathway | Synthetase | breast cancer |
FABP7 | fatty acid binding protein 7, brain | 2173 | Lipid and fatty acid transport;Lipid and fatty acid binding; Vitamin/cofactor transport;Steroid hormone-mediated signaling;Transport;Ectoderm development | Transfer/carrier protein | breast cancer |
ANXA4 | annexin A4 | 307 | Lipid, fatty acid and steroid metabolism | Transfer/carrier protein;Annexin | pancreatic cancer |
ANXA5 | Annexin V | 308 | Lipid, fatty acid and steroid metabolism | Transfer/carrier protein;Annexin | breast and pancreatic cancers |
ACAT1 | acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase) | 38 | Protein acetylation | Acetyltransferase | liver cancer |
HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 3329 | Protein folding;Protein complex assembly | Chaperonin | lung cancer |
HSPB1 | heat shock 27kDa protein 1 | 3315 | Protein folding;Stress response | Chaperones | Colon, breast, ovarian cancer and pancreatic cancers |
HSPCB | heat shock 90kDa protein 1, beta | 3326 | Protein folding;Stress response | Hsp 90 family chaperone | |
CSTB | cystatin B (stefin B) | 1476 | Proteolysis | Cysteine protease inhibitor | prostate cancer |
PSME2 | proteasome (prosome, macropain) activator subunit 2 (PA28 beta) | 5721 | Proteolysis | Miscellaneous function protein | breast cancer |
CALB1 | calbindin 1, 28kDa | 793 | Calcium mediated signaling;Calcium ion homeostasis | Select calcium binding protein | |
TBB2 | tubulin, beta polypeptide | 7280 | Intracellular protein traffic;Chromosome segregation;Cell structure;Cell motility | Protein polymerization | breast cancer |
ATP5D | ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit | 513 | Nucleoside, nucleotide and nucleic acid metabolism;Electron transport;Cation transport | Hydrogen transporter;Synthase;Other hydrolase | lung cancer |
ATP5H | ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d | 10476 | ATP synthesis coupled proton transport | ATP synthase | lung and ovarian cancer |
HINT1 | histidine triad nucleotide binding protein 1 (PKCi substrate analog) | 3094 | Signal transduction | Nucleotide phosphatase | breast cancer |