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Table 1 Gene expression effects of retroviral Rb transduction

From: Rb induces a proliferative arrest and curtails Brn-2 expression in retinoblastoma cells

Gene

Probe Set Accession #

Fold Change

Controls

  

GAPDH

M33197_M_at

0.92

 

M33197_3_at

0.91

 

M33197_5_at

0.82

β-actin

200801_x_at

1.07

E2F-responsive

  

CDC2

203214_x_at

0.53

 

210559_s_at

0.63

 

203213_at

0.70

 

231534_at

0.43*

CDC25A

204695_at

0.60

 

1555772_a_at

0.76

CDC25B

201853_s_at

0.93

CDC25C

205167_s_at

0.89

CDK2

204252_at

0.38*

Cyclin A2

203418_at

0.61

Cyclin B1

214710_s_at

0.74

 

228729_at

0.76

Cyclin B2

202705_at

0.76

Cyclin E1

213523_at

0.92

Cyclin E2

211814_s_at

0.37*

 

205034_at

0.61

E2F1

204947_at

0.92

 

2028_s_at

0.67

E2F2

228361_at

0.56

E2F3

203692_s_at

1.31

 

203693_s_at

1.02

EMI1 (FBXO5)

218875_s_at

0.66

 

234863_x_at

0.55

Geminin

218350_s_at

0.63

HPRT

202854_at

0.65

N-myc

209757_s_at

1.06

PCNA

201202_at

0.90

PLK

214372_x_at

0.80

 

202240_at

0.42*

RbL1 (p107)

1555004_a_at

0.44*

Ribonuc. Reductase M1

201477_s_at

0.65

 

201476_s_at

0.50

Ribonuc. Reductase M2

209773_s_at

0.74

SKP2

210567_s_at

1.16

 

203626_s_at

0.77

Thymidlyate Synthase

202589_at

0.74

 

1554696_s_at

0.57

Thymidine Kinase

243103_at

0.98

 

1554408_a_at

0.82

 

202338_at

0.59

Novel

  

Brn-2 (POU3F2)

207084_at

0.05**

  1. Affymetrix U133 Plus 2.0 microarrays were hybridized with probes from vector- and Rb-transduced cells and analyzed with Affymetrix Microarray Suite software. The indicated probe sets were flagged as "Present" in vector transduced samples, and showed the indicated fold change in signal for Rb-transduced versus vector-transduced samples. Asterisks indicate probe sets with fold change less than 0.5. The double asterisk indicates one of the most strongly down-regulated genes in the microarray analysis.
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Molecular Cancer

ISSN: 1476-4598