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Table 5 GOstat analysis of biological processes.

From: Investigation of the molecular profile of basal cell carcinoma using whole genome microarrays

GO Number

Observed Transcripts

Total Transcripts

GO Category

P value

GO:0006119

36

138

oxidative phosphorylation

2.77E-34

GO:0006091

120

1003

generation of precursor metabolites and energy

3.75E-33

GO:0016491

123

1170

oxidoreductase activity

7.47E-26

GO:0006732

44

269

coenzyme metabolism

5.71E-21

GO:0006629

86

765

lipid metabolism

1.17E-20

GO:0003954

24

62

NADH dehydrogenase activity

8.07E-16

GO:0043037

40

280

translation

4.26E-15

GO:0016651

27

99

oxidoreductase activity, acting on NADH or NADPH

1.63E-13

GO:0016126

16

31

sterol biosynthesis

5.82E-13

GO:0008135

29

185

translation factor activity, nucleic acid binding

8.99E-13

GO:0045045

30

217

secretory pathway

1.31E-10

GO:0006099

14

45

tricarboxylic acid cycle

5.49E-08

GO:0046356

14

45

acetyl-CoA catabolism

5.49E-08

GO:0006511

25

201

ubiquitin-dependent protein catabolism

2.83E-07

GO:0006413

17

84

translational initiation

1.20E-06

GO:0048193

19

108

Golgi vesicle transport

2.00E-06

GO:0006412

87

1228

protein biosynthesis

5.29E-06

GO:0008289

35

380

lipid binding

2.46E-05

GO:0006445

15

92

regulation of translation

7.85E-05

GO:0006888

13

72

ER to Golgi vesicle-mediated transport

9.90E-05

GO:0006915

49

644

apoptosis

0.000214

GO:0008415

20

190

acyltransferase activity

0.000313

GO:0006944

7

32

membrane fusion

0.00289

GO:0016281

4

9

eukaryotic translation initiation factor 4F complex

0.00313

GO:0006984

4

9

ER-nuclear signaling pathway

0.00313

GO:0044242

7

33

cellular lipid catabolism

0.00349

GO:0030503

3

5

regulation of cell redox homeostasis

0.00611

GO:0007050

11

85

cell cycle arrest

0.00717

GO:0016282

5

27

eukaryotic 43S preinitiation complex

0.0303

  1. Biological processes that are significantly enriched in our set of 1,813 transcripts found to be significantly down-regulated in BCC compared to normal skin specimens. Shown here is a sub-set of 29 representative significant GO annotations.