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Table 1 Immunohistochemical Staining for Perlecan and Co-Localization with Ki-67.

From: Perlecan, a candidate gene for the CAPB locus, regulates prostate cancer cell growth via the Sonic Hedgehog pathway

   Perlecan Negative Perlecan Positive  
Histology Tumor 170 203  
  Normal 211 31 p < 0.00005
  Tumor 170 203  
  HGPIN 46 7 p < 0.00005
Clinical Stage cT2 11 12  
  cT3/4 2 3 N.S.
Tumor Grade Gleason 6 26 5  
  Gleason 7,8,9 38 23 p = 0.0335
Pathologic Stage pT1-pT2 35 17  
  pT3 29 11 N.S.
Nodal Status pN0 18 23  
  pN1 0 1 N.S.
Outcomes PSA Recurrence 4 5  
  No PSA Recurrence 13 22 N.S.
Vital Status Alive 26 36  
  Dead 2 5 N.S.
Perlecan Expression in Metastasis
Metastatic Site   Perlecan Negative Perlecan Positive P value vs. Prostate
Primary Tumor (Prostate)   3 24  
Lymph Node   8 9 p = 0.0073
Soft Tissue   15 18 p = 0.0039
Liver   5 23 p = 0.4781
Lung   3 24 p = 1.000
Association of Ki-67 (PCNA) Staining with Perlecan Staining
Sample Staining   Number of Samples Mean % of Ki-67 positivity Two-tailed ANOVA
Perlecan positive   143 6.715278 p = 0.0478
Perlecan negative   214 5.028571  
  1. * Tumor grade is presented as Gleason score. Pathologic staging uses the American Joint Commission on Cancer (AJCC) 2002 tumor staging criteria. HGPIN = high grade prostatic intraepithelial neoplasia.