Figure 3
From: Identification of candidate methylation-responsive genes in ovarian cancer
Methylation analysis of the EMP3, CAV1 and CXCL6 genes in ovarian cancer (EOC) and control (NOSE) tissues. Summary of sodium bisulfite sequencing analysis of CGIs associated with the EMP3, CAV1 and CXCL6 genes in ovarian ovarian cancer and control (NOSE) tissues. For EMP3, 16 clones for 4 cancer samples and 23 clones for 5 control (NOSE) samples were sequenced. For CAV 1, 17 clones for 4 cancer samples and 18 clones for 4 control (NOSE) samples were sequenced. For CXCL6, 19 clones for 4 cancer samples and 24 clones for 5 normal (NOSE) samples were sequenced. Each circle displays the percent methylation of all clones for a single CpG dinucleotide (open circle, 100% unmethylated; filled circle, 100% methylated). Average percent methylation for cancer (EOS) and control (NOSE) samples is shown next to each row of circles. (Vertical bars, CpG dinucleotides; arrow, position of the transcription start site; horizontal black rectangle, region amplified and sequenced after sodium bisulfite).