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Table 3 Overview of the sample content of the Ovarian Germ Cell tumour – Tissue Microarray

From: Ovarian dysgerminomas are characterised by frequent KIT mutations and abundant expression of pluripotency markers

Diagnosis of tumour(s)

 

No. CORES

No. PATIENTS

Histology of analysed component(s)

Pure DG

- Unilateral

- Bilateral

10

3

10

2

DG

1 case one side; 1 case both sides

DG/GB

- Unilateral

- Bilateral

3

6

3

3

2 cases DG and GB; 1case only DG

Pure YST

- Unilateral

7

7

YST

Pure IT

- Unilateral

15

15

IT

Mixed OGCT: DG/YST

- Unilateral

- Bilateral

2

2

1

1

DG and YST

DG and YST

Mixed OGCT: YST/EC

- Unilateral

1

1

YST

Mixed OGCT: DG/EC/GB

- Unilateral

3

1

DG, EC, and GB

Mixed OGCT: YST/IT

- Unilateral

6

5

3 cases only YST; 1 case only IT; 1 case YST and IT

Mixed OGCT: DG/CC

- Unilateral

2

1

DG and CC

SCC

- Unilateral

8

8

SCC

  1. The tissue microarray (TMA) contained of 60 cores obtained from OGCTs of 50 patients and 8 small cell carcinomas from 8 patients. Six patients exhibited bilateral neoplasia. H&E stained sections from several blocks were re-evaluated by a pathologist (V.M.A.), classified according to the WHO recommendations [1], and the most optimal tissue blocks were chosen. The TMA was constructed by transferring core biopsies of 0.6 μm in diameter from each donor block into an acceptor block (Beecher Instruments, Sun Prairie, USA). Abbreviations: GCT = germ cell tumour; No. = number; DG = dysgerminoma; GB = gonadoblastoma; YST = yolk sac tumour; IT = immature teratoma; EC = embryonal carcinoma; CC = choriocarcinoma; SCC = small cell carcinoma.