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Table 3 Overview of the sample content of the Ovarian Germ Cell tumour – Tissue Microarray

From: Ovarian dysgerminomas are characterised by frequent KIT mutations and abundant expression of pluripotency markers

Diagnosis of tumour(s)   No. CORES No. PATIENTS Histology of analysed component(s)
Pure DG - Unilateral
- Bilateral
10
3
10
2
DG
1 case one side; 1 case both sides
DG/GB - Unilateral
- Bilateral
3
6
3
3
2 cases DG and GB; 1case only DG
Pure YST - Unilateral 7 7 YST
Pure IT - Unilateral 15 15 IT
Mixed OGCT: DG/YST - Unilateral
- Bilateral
2
2
1
1
DG and YST
DG and YST
Mixed OGCT: YST/EC - Unilateral 1 1 YST
Mixed OGCT: DG/EC/GB - Unilateral 3 1 DG, EC, and GB
Mixed OGCT: YST/IT - Unilateral 6 5 3 cases only YST; 1 case only IT; 1 case YST and IT
Mixed OGCT: DG/CC - Unilateral 2 1 DG and CC
SCC - Unilateral 8 8 SCC
  1. The tissue microarray (TMA) contained of 60 cores obtained from OGCTs of 50 patients and 8 small cell carcinomas from 8 patients. Six patients exhibited bilateral neoplasia. H&E stained sections from several blocks were re-evaluated by a pathologist (V.M.A.), classified according to the WHO recommendations [1], and the most optimal tissue blocks were chosen. The TMA was constructed by transferring core biopsies of 0.6 μm in diameter from each donor block into an acceptor block (Beecher Instruments, Sun Prairie, USA). Abbreviations: GCT = germ cell tumour; No. = number; DG = dysgerminoma; GB = gonadoblastoma; YST = yolk sac tumour; IT = immature teratoma; EC = embryonal carcinoma; CC = choriocarcinoma; SCC = small cell carcinoma.