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Figure 1 | Molecular Cancer

Figure 1

From: Integrative analysis of a cancer somatic mutome

Figure 1

Integration of LOH, CN and expression data to better define candidate tumor suppressors and oncogenes for the breast cancer neoplastic process. Examples of LOH and CN analyses: (A) LOH analysis for HSA1 shows three critical regions (defined by close boundaries of LOH) indicated by pink lines across tumor samples; (B) CN analyses indicate GAB1 locus genomic amplification in HSA4, and SORL1 and TECTA loci genomic loss in HSA11; and (C) Integration of LOH and CN, and differential expression in tumors relative to healthy tissues indicate candidate tumor suppressors (down-regulated in tumors, green) and oncogenes (up-regulated in tumors, red) in four different types of breast tumors as indicated by numbers in brackets.

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