Figure 5

Human interactome network analysis, direct interactions between mutome gene products. (A) Left panel, direct interactions between validated mutome and/or benchmark gene products. Right panel, interactions centered on SPTAN1, whose expression level predicts survival (Fig. 3). Grey nodes represent non-mutome/benchmark proteins. (B) Network generated by direct protein interactions between validated and non-validated mutome and/or benchmark gene products (top left inset). An image of the largest component of this network is shown, with critical nodes that connect benchmark or mutome proteins indicated by arrows. (C) Clusters or densely connected regions in the interactome network that contain more mutome gene products than expected by chance: cluster A shows enrichment in annotations of the TGF-beta and insulin signaling pathways and of DNA transcriptional activity; cluster B shows enrichment for centrosome-related tasks and DNA transcriptional activity.