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Table 1 Clinical, methylation and CGH data for prostate cancer tissues

From: Factor interaction analysis for chromosome 8 and DNA methylation alterations highlights innate immune response suppression and cytoskeletal changes in prostate cancer

Tumor No. Stage Gleason Score Molecular Group LINE-1 %hypo No. hypem. genes Chromosomal losses Chromosomal gains
36 pT3bN0 7   1 4 - 3q21q26.2
38 pT2N0 7   4 4 - -
50 pT3bN0 7 hypo 10 4 1q31 6p,7p,16p,17p, 18p,19, 20q13,21,22,Y
65 pT3bN0 7 both 9 4 Y 1p33p34.3, 2p21p23, 2q14.1q14.3, 2q33q36, 3p14.1p21.3, 3q25.1q26.3, 4q13.3q28, 5q22, 5q31.2q32, 6q16.1q22.1, 8q22.1q23, 10p11.2p13, 10q11.2q22.3, 12q13.2q24.31, 13q21.1q31, 14q21q32.2, 18q11.2q22, Xp21.3q27
83 pT3bN0 7 hypo 6 4 1q31, 2q33q37, 4q31, 13q21q31, 15q24, 4q12, 5q13, 17p, 18p, 19, Y
89 pT2bN0 3 hypo 5 2 9q33q34, X 2q11q24, 4q12q22, 6q22, 12p,18p, Y
93 pT3bN0 7   4 4 - Yq
95 pT3bN1 10 hypo 7 4 Xq 18p, Y
99 pT2bN0 5   0 1 - 2q14q24,10q11q21
101 pT3aN0 8 none 0 3 1p36, 14q31q32, 17p, 22 -
105 pT3aN0 5   1 1 1p36,2,3,4 -
107 pT3aN0 7 none 3 4 18p, Y 4q24, 6q22, Xp11.2p11.4
117 pT3bN0 5   3 4 - 1q21q25,2q11q14,19q13
119 pT3bN1 9 none 1 3 7p15pter, 15q23qter, Y 10q21q22
121 pT2bN0 6 chrom8 1 4 1q32q41, 3p21, 4p15p16, 8p22p23, 9p23p24,10q25q26, 11q23q25, 12q24, 13q32q34, 14q24q32, 15q24q26, 17q24q25, Xp21p22 Yq
123 pT2aN0 5   1 1 9q21.2q21.3, 10q26, 16p, Y 2p14p16, 2q24.3q32.1, 6q14q16.1
125 pT2bN0 6   1 0 14q31 -
127 pT2bN0 7 none 2 2 7q36, Yq 2q22q32.3, 4q11q31.3, 13q14.1q21.1, 14q21q23, 15q21.1q23
133 pT2bN1 7 chrom8 0 4 22, Y 1q, 2q22q34, 3q11.1q26.1, 4q22q27, 5q21q31, 6q21q24, 8q11q23, 10q11q21.3, 12q21q22, 14q12q22, X
137 pT2bN0 8 chrom8 1 1 16, 17, 18p, 18q11.1q21.1, 19, 21q22, Y 3q23q26.3, 4q13.2q21.3, 5q, 7q13q31, 8p21pter, 8q24, 9p, 14q13qter
139 pT3bN1 9 chrom8 1 4 19q, Y 1q25q31, 2q11q33, 3, 4q, 5q13q23, 6q14q25, 7q21qter, 8q13q23, 11q14qter, 13q21q32, 14q11.1q21, 18q12, Xq21.3qter
141 pT2bN0 4 chrom8 0 2 16, 17, 18p, 19, 20, 22, Y 1q31q32.1, 2, 3q13.3qter, 4q11q31.1, 5q14qter, 6q, 7p12pter, 7q22q31.2, 8q12q21.2, 10q21.1q23.1, 11q14.3qter, 12q14qter, 13q14.1qter
145 pT4N1 7 hypo 11 3 Y 3q25q27,4q24q26,7q11q22,13q31q34,17p,18p
149 pT2bN0 6   2 2 Y 2p, 4p12, 4q24q26, 5q11q13, 7p12, 8q23q24, 9,11q22, 12q12q15, 14q24, 17, 19, 20q13,
151 pT3aN0 7   0 1 3p13p14 6p14, Xp21
153 pT3aN0 5   2 1   Xq11.2q13
155 pT3aN0 5   5 4 19p 3p25p26, Y
157 pT2aN0 8   2 0 - 1q21q31, 2q12q24, 3q, 4q12q21, 5q13q14, 6q14q16, 7q11, 8q12q22, 12q12q13, 18p, Y
161 pT2bN0 5   3 4 15q22q24, Xq22q25 -
163 pT3bN1 5 chrom8 2 2 16, 17p, 18p, 20, Y 1q25qter, 2p11p16, 2q32q34, 3q12, 3q21q27, 4q, 6q15q24, 8q12q21, 8q23q24, 12q13q21, 13q14q32, 14q12q21, 18q, Xq11.1q26
169 pT3aN0 7 chrom8 3 2 16, 17p, 18p, 19, Y 2, 3, 4q, 5q, 7p15pter, 8q22q24, 13q31qter, 14q24qter, 17q23, 18q21qter, Xq21.3q26
171 pT2bN0 5 hypo 8 4 10q26, 18p. -19, 22, Y 1p31, 2p12p13, 2q11q34, 4q22q26, 5q22, 6q11q23, 14q22q24, X
175 pT2bN0 8   11 4 13q14 -
183 pT3aN0 6   19 4 1p36,9q34 -
187 pT2bN0 8 chrom8 1 3 16, 17p, 18p, 19, 21, 22, Y 1, 2, 3q13qter, 4q, 5q14q33.1, 6q16q23, 7p, 7q22q33, 8q, 11q14.3qter, 12q14qter, 13q21qter, 14q24q31, 15q, Xq22qter
189 pT2bN0 7 none 0 4 3p25p26, 10q26, Xq22qter, Yq -
191 pT2bN0 7   0 3 4q31, 5q31q35, 9q33, 12p12 -
205 pT3aN0 7   5 1 18p, 19, 22, Y 2q31q33, 6q22.3q23, 10q21q22, Xp11.1p11.4, Xq
209 pT3aN0 7 both 8 4 1p36, 8p, 16, 17, 18p, 19, 20, 22, Y 1q31q32.1, 2q11.1q34, 3, 4q21.1qter, 5q14q31, 6q11q23, 7q21q34, 8q, 9, 11q14q22, 12q15q24, 13q14qter, 18q
213 pT2aN0 7   8 4 8q24.2qter, 14q32, 16, 17, 18p, 22, Y -
215 pT3aN0 7   9 4 19q13, 22q13,Y 3q24q26, 5q12, 8p12, 17, 18, Xp11p21, X21q24
217 pT2bN0 8   5 4 18p13, Y 2q33q35, 4q13q28,5q21q31,8q21,8q24,12q13, 12q21q23, Xq13q25
219 pT4N1 7 both 21 4 5q34qter, 8p22pter, 19, Yq 1p22p31.3, 4q21q22, 4q31.1, 5q13, 6q24q26, 7q, 8q21q24, 10q21, 11q14q22, 20q13, Xq13q22
225 pT3bN0 6   4 4 4q28, 8q24qter, Yq -
227 pT2aN1 7   3 4 22q13 3q11q21
232 pT2bN1 7 both 13 4 8p22pter -
245 pT3aN0 7   4 3 17p13, 18p 1p31
247 pT3bN1 7 chrom8 3 3 8p21pter, 9q21, 22, Y Xq12
253 pT3aN1 7   1 4 1p36, 2q33q37, 6p21.3p25, 8p21, 14q31q32, Y -
256 pT3bN0 7   1 4 2p2p21, 6q, 15q26,16p, 18,X -
  1. The numbers of the tumors used in the microarray analysis are in bold type, as are hypomethylation values considered significantly elevated (< 4%) and typical chromosome 8 aberrations. All cancers were M0 at the time of prostatectomy. No. hypermethylated genes indicates hypermethylation of APC, GSTP1, RARB2, and RASSF1A. LINE-1 hypomethylation was determined by Southern blot analysis. Chromosomal dosage changes were determined by comparative genomic hybridization.
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Molecular Cancer

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