Figure 9From: Attenuation of PTEN increases p21 stability and cytosolic localization in kidney cancer cells: a potential mechanism of apoptosis resistanceAkt phosphorylation is reduced by PI3K inhibition. Wild type ACHN cells were incubated with (a) LY-294,002 (10 μM) or (b) wortmannin (50 nM) for the times indicated and immunoblotted with antibodies against Akt, phospho-Akt, or β-actin. A representative experiments is shown of three done.Back to article page