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Table 3 Genes (n = 20), located to chromosome arm 5p that are upregulated in carcinomatoses.

From: Gene expression profiles of primary colorectal carcinomas, liver metastases, and carcinomatoses

Genebank Acc

Gene Symbol

Gene Name

Fold change carcinomatoses

Fold change liver

Folde change primary

Fold change carcinomatoses as compared to liver and primary

L28175

PTGER4

Prostaglandin E receptor 4 (subtype EP4)

1.02

-4.41

-2.03

4.24

AK024116

FLJ14054

Hypothetical protein FLJ14054

1.20

-2.06

-3.46

3.96

AB061834

RPL37

Ribosomal protein L37

3.62

-1.02

1.04

3.61

BC000518

BASP1

Brain abundant, membrane attached signal protein 1

1.18

-1.96

-1.65

2.98

AF155135

RAI14

Retinoic acid induced 14

1.78

-1.35

-1.02

2.96

AF064876

HCN1

Hyperpolarization activated cyclic nucleotide-gated potassium channel 1

1.53

-1.31

-1.18

2.77

AK001989

FLJ11127

Hypothetical protein FLJ11127

1.25

-1.16

-1.52

2.58

BC008752

ZNF622

Zinc finger protein 622

1.29

-1.36

-1.05

2.49

AB020647

FBXL7

F-box and leucine-rich repeat protein 7

1.43

-1.03

-1.09

2.49

AK025310

FLJ21657

Hypothetical protein FLJ21657

1.07

-1.62

-1.15

2.45

U28043

SLC9A3

Solute carrier family 9 (sodium/hydrogen exchanger), isoform 3

1.01

-1.45

-1.39

2.43

BC001380

SDHA

Succinate dehydrogenase complex, subunit A, flavoprotein (Fp)

1.34

-1.04

-1.05

2.39

AF338650

PDZK3

PDZ domain containing 3

1.02

-1.68

-1.02

2.37

AB019494

NIPBL

Nipped-B homolog (Drosophila)

1.28

-1.13

-1.03

2.36

AF009301

MARCH-VI

Membrane-associated RING-CH protein VI

1.15

-1.32

-1.06

2.34

BC022339

PC4

Activated RNA polymerase II transcription cofactor 4

1.12

-1.28

-1.07

2.30

BC003353

MGC5309

Hypothetical protein MGC5309

1.15

-1.18

-1.08

2.27

AF189011

RNASE3L

Nuclear RNase III Drosha

1.04

-1.35

-1.07

2.26

BC017586

MGC26610

Hypothetical protein MGC26610

1.17

-1.08

-1.06

2.24

AY029177

SKP2

S-phase kinase-associated protein 2 (p45)

1.04

-1.00

-1.07

2.08

  1. Ratios; expression in fold change using medians of each group as compared to normal colonic tissue. Fold change carcinomatoses; expression fold in carcinomatoses – (fold in liver metastases + primaries)/2.
  2. Genes in bold are upregulated in the carcinomatoses cell line IS3.