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Table 4 Genes in common among in vivo tumors and in vitro cell lines.

From: Gene expression profiles of primary colorectal carcinomas, liver metastases, and carcinomatoses

Genebank Acc. Gene Symbol Gene Name Z-cut Stage Fold change IS1 Fold change IS2 Fold change IS3
X78947 CTGF connective tissue growth factor 2,65 C   1.11 1.59
AF067817 VAV3 vav 3 oncogene -2,63 C -24.77 -3.89 -1.23
AL834404 NETO2 neuropilin (NRP) and tolloid (TLL)-like 2 -2,59 C 1.82 1.21 -12.01
NM_016234 ACSL5 acyl-CoA synthetase long-chain family member 5 -2,52 C -4.64 -1.75 -3.09
NM_139160 LOC91614 novel 58.3 KDA protein -2,46 C -2.23 -1.59 2.58
M55905 ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial -2,41 C 1.21 -1.80 -1.66
NM_000620 NOS1 nitric oxide synthase 1 (neuronal) 4,15 L 2.06 2.51 -1.69
NM_013317 T1A-2 lung type-I cell membrane-associated glycoprotein -3,95 L -9.86 -12.64 -2.37
AK097373 CYP4Z2P cytochrome P450 4Z2 pseudogene 3,92 L 1.78 1.19 -15.97
X98311 CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7 3,92 L 1.59 1.41 -7.00
NM_139284 LGI4 leucine-rich repeat LGI family, member 4 3,86 L 2.12 1.55 -3.53
AF227137 TAS2R13 taste receptor, type 2, member 13 3,81 L 1.35 1.20 5.73
K00422 HP haptoglobin 3,70 L 1.32 1.33 1.64
NM_001848 COL6A1 collagen, type VI, alpha 1 -3,62 L -5.51 -39.77 -1.60
X04898 APOA2 apolipoprotein A-II 3,57 L 7.16 5.61 -1.18
BC016147 NR4A1 nuclear receptor subfamily 4, group A, member 1 -3,41 L -6.69 -3.26 -6.91
NM_173650 DNAJC5G DnaJ (Hsp40) homolog, subfamily C, member 5 gamma 3,37 L 2.20 2.70 -3.42
NM_152576 MGC24103 hypothetical protein MGC24103 -3,36 L -9.78 -14.62 -1.10
AK056254 KRT4 keratin 4 3,36 L 2.17 1.34 -8.59
NM_004671 PIAS2 protein inhibitor of activated STAT, 2 3,29 L 1.96 1.19 2.16
AF328788 AMN amnionless homolog (mouse) 3,12 L 2.44 3.06 -6.08
BC007287 ZNF213 zinc finger protein 213 3,07 L 3.11 1.81 -2.05
BC012125 SLC39A8 solute carrier family 39 (zinc transporter), member 8 -3,04 L -4.10 -2.34 2.97
NM_020249 ADAMTS9 a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 9 -2,98 L 1.03 -1.45 -2.91
M60828 FGF7 fibroblast growth factor 7 (keratinocyte growth factor) -2,95 L -7.06 -8.61 -15.00
M98398 CD36 CD36 antigen (collagen type I receptor, thrombospondin receptor) -3,17 P -23.00 -21.88 1.11
NM_033201 BC008967 hypothetical gene BC008967 -2,95 P -7.38 -4.64 -2.15
BC001634 VAMP8 vesicle-associated membrane protein 8 (endobrevin) -2,78 P -1.78 -2.89 2.65
NM_022912 C2orf23 chromosome 2 open reading frame 23 -2,72 P -4.00 -7.64 1.80
M27110 PLP1 proteolipid protein 1 (Pelizaeus-Merzbacher disease, spastic paraplegia 2, uncomplicated) -2,67 P -3.05 -4.03 1.94
AB038518 COLEC12 collectin sub-family member 12 -2,62 P -9.65 -9.96 -10.22
AB020629 ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 -2,60 P -1.85 -2.07 -6.80
Y12653 UBD ubiquitin D 2,60 P 2.07 1.72 1.35
AK025416 UGCGL1 UDP-glucose ceramide glucosyltransferase-like 1 -2,60 P -5.63 -3.92 1.81
AK021429 SH3MD2 SH3 multiple domains 2 -2,59 P -1.07 -1.26 2.22
NM_032727 INA internexin neuronal intermediate filament protein, alpha -2,54 P -2.19 -2.48 -1.06
AK074207 SLC37A2 solute carrier family 37 (glycerol-3-phosphate transporter), member 2 -2,50 P -2.68 -2.25 1.38
AJ001014 RAMP1 receptor (calcitonin) activity modifying protein 1 -2,46 P -6.00 -4.48 -44.44
AB007895 FLJ11383 hypothetical protein FLJ11383 -2,41 P -1.11 1.09 2.92
NM_016397 TH1L TH1-like (Drosophila) 2,40 P 2.39 2.35 -1.27
  1. Z-cut is derived from BAMarray., L; liver metastases, C; carcinomatoses, P; primary carcinomas Fold change; expression in fold change as compared to normal colonic tissue. Genes shown in bold are most dysregulated in the corresponding cell line when compared to solid tumors.