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Table 4 Genes in common among in vivo tumors and in vitro cell lines.

From: Gene expression profiles of primary colorectal carcinomas, liver metastases, and carcinomatoses

Genebank Acc.

Gene Symbol

Gene Name

Z-cut

Stage

Fold change IS1

Fold change IS2

Fold change IS3

X78947

CTGF

connective tissue growth factor

2,65

C

 

1.11

1.59

AF067817

VAV3

vav 3 oncogene

-2,63

C

-24.77

-3.89

-1.23

AL834404

NETO2

neuropilin (NRP) and tolloid (TLL)-like 2

-2,59

C

1.82

1.21

-12.01

NM_016234

ACSL5

acyl-CoA synthetase long-chain family member 5

-2,52

C

-4.64

-1.75

-3.09

NM_139160

LOC91614

novel 58.3 KDA protein

-2,46

C

-2.23

-1.59

2.58

M55905

ME2

malic enzyme 2, NAD(+)-dependent, mitochondrial

-2,41

C

1.21

-1.80

-1.66

NM_000620

NOS1

nitric oxide synthase 1 (neuronal)

4,15

L

2.06

2.51

-1.69

NM_013317

T1A-2

lung type-I cell membrane-associated glycoprotein

-3,95

L

-9.86

-12.64

-2.37

AK097373

CYP4Z2P

cytochrome P450 4Z2 pseudogene

3,92

L

1.78

1.19

-15.97

X98311

CEACAM7

carcinoembryonic antigen-related cell adhesion molecule 7

3,92

L

1.59

1.41

-7.00

NM_139284

LGI4

leucine-rich repeat LGI family, member 4

3,86

L

2.12

1.55

-3.53

AF227137

TAS2R13

taste receptor, type 2, member 13

3,81

L

1.35

1.20

5.73

K00422

HP

haptoglobin

3,70

L

1.32

1.33

1.64

NM_001848

COL6A1

collagen, type VI, alpha 1

-3,62

L

-5.51

-39.77

-1.60

X04898

APOA2

apolipoprotein A-II

3,57

L

7.16

5.61

-1.18

BC016147

NR4A1

nuclear receptor subfamily 4, group A, member 1

-3,41

L

-6.69

-3.26

-6.91

NM_173650

DNAJC5G

DnaJ (Hsp40) homolog, subfamily C, member 5 gamma

3,37

L

2.20

2.70

-3.42

NM_152576

MGC24103

hypothetical protein MGC24103

-3,36

L

-9.78

-14.62

-1.10

AK056254

KRT4

keratin 4

3,36

L

2.17

1.34

-8.59

NM_004671

PIAS2

protein inhibitor of activated STAT, 2

3,29

L

1.96

1.19

2.16

AF328788

AMN

amnionless homolog (mouse)

3,12

L

2.44

3.06

-6.08

BC007287

ZNF213

zinc finger protein 213

3,07

L

3.11

1.81

-2.05

BC012125

SLC39A8

solute carrier family 39 (zinc transporter), member 8

-3,04

L

-4.10

-2.34

2.97

NM_020249

ADAMTS9

a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 9

-2,98

L

1.03

-1.45

-2.91

M60828

FGF7

fibroblast growth factor 7 (keratinocyte growth factor)

-2,95

L

-7.06

-8.61

-15.00

M98398

CD36

CD36 antigen (collagen type I receptor, thrombospondin receptor)

-3,17

P

-23.00

-21.88

1.11

NM_033201

BC008967

hypothetical gene BC008967

-2,95

P

-7.38

-4.64

-2.15

BC001634

VAMP8

vesicle-associated membrane protein 8 (endobrevin)

-2,78

P

-1.78

-2.89

2.65

NM_022912

C2orf23

chromosome 2 open reading frame 23

-2,72

P

-4.00

-7.64

1.80

M27110

PLP1

proteolipid protein 1 (Pelizaeus-Merzbacher disease, spastic paraplegia 2, uncomplicated)

-2,67

P

-3.05

-4.03

1.94

AB038518

COLEC12

collectin sub-family member 12

-2,62

P

-9.65

-9.96

-10.22

AB020629

ABCA8

ATP-binding cassette, sub-family A (ABC1), member 8

-2,60

P

-1.85

-2.07

-6.80

Y12653

UBD

ubiquitin D

2,60

P

2.07

1.72

1.35

AK025416

UGCGL1

UDP-glucose ceramide glucosyltransferase-like 1

-2,60

P

-5.63

-3.92

1.81

AK021429

SH3MD2

SH3 multiple domains 2

-2,59

P

-1.07

-1.26

2.22

NM_032727

INA

internexin neuronal intermediate filament protein, alpha

-2,54

P

-2.19

-2.48

-1.06

AK074207

SLC37A2

solute carrier family 37 (glycerol-3-phosphate transporter), member 2

-2,50

P

-2.68

-2.25

1.38

AJ001014

RAMP1

receptor (calcitonin) activity modifying protein 1

-2,46

P

-6.00

-4.48

-44.44

AB007895

FLJ11383

hypothetical protein FLJ11383

-2,41

P

-1.11

1.09

2.92

NM_016397

TH1L

TH1-like (Drosophila)

2,40

P

2.39

2.35

-1.27

  1. Z-cut is derived from BAMarray., L; liver metastases, C; carcinomatoses, P; primary carcinomas Fold change; expression in fold change as compared to normal colonic tissue. Genes shown in bold are most dysregulated in the corresponding cell line when compared to solid tumors.