Figure 2

Active mismatch repair system in primary tumors help in the induction of cell death after chemotherapy. Primary tumors containing heterogeneous population of tumor cells along with small % of cancer stem cells (CSCs, represented by dark gray colored oval shape undergo chemotherapy. Presence of active mismatch repair induces cellular response followed by apoptosis, which lead to cell death. However, mismatch repair deficiency makes tumor cells insensitive to drug and it relapses.