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Figure 2 | Molecular Cancer

Figure 2

From: HHV-8 encoded LANA-1 alters the higher organization of the cell nucleus

Figure 2

LANA-1 (green) dissolves DNA (blue) from perinucleolar heterochromatin in transfected MCF7 cells. Increasing amount of transfected LANA-1 (compare top to the middle or bottom panels) leads to the elimination of the DNA staining (blue) in the perinucleolar heterochromatic rings. Adjacent non-transfected cells serve as controls. Right panel shows magnified pictures of chromatin organization of the selected nuclear areas selected by red border boxes in the left panel. The middle and bottom panels represent the two distinct types of chromatin effects: The smoothing out of the chromatin staining (middle panel) versus induction of newly condensed chromatin cords (bottom panel). Importantly both changes lead to the elimination of perinucleolar heterochromatin.

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