Figure 1

Using by the malignant tumor cell of the mechanisms involved in the inflammatory response. a : Ischemicphenotype. Oxidative stress is produced from the anoxia until the beginning of the oxygenation (hypoxia) and the tumor cell becomes independent (autocrine) and acquires motility. In this phase nutrition by diffusion stands out. b: Leukocytic phenotype. A provisional matrix is developed by hypercoagulation. The hyperproduction of enzymes, chemokines and cytokines induce the lymphatic migration (paracrine), as well as the uptake of nutrients by the cancer cell. c : Angiogenic phenotype. Angiogenesis makes it possible that a number of host substances, including hormones (endocrine) would be used by the tumor cell in its own metabolism. This fact favor its excessive growth and the metabolic manipulation of the host inducing cachexia. SC: Stem cell; SHC: Stem hematopoietic cell; P: plasma; Pt: Platelets. PMN: Polimorphonuclear neutrophils; MN: Monocite; L: Limphocyte; RBC: red blood cells; TC: Tumor cell; ep: epithelial cell ; N: node; T: Tumor, M: Metastasis.