A novel small molecule that selectively inhibits glioblastoma cells expressing EGFRvIII

Table 1 IC₅₀data for NSC-154829

NSC Number	IC ₅₀ 897/898 clone 1	IC ₅₀ 897/898 clone 2	IC ₅₀ 897/898 clone 3	IC ₅₀ D54/54E trial #1	IC ₅₀ D54/54E trial #2	IC ₅₀ D54/54E trial #3
154829	0.77 (0.71–0.84); 0.56 (0.51–0.69);	0.63 (0.49–0.81); 0.36 (0.35–0.38)	0.62 (0.54–0.71); 0.27 (0.24–0.30);	0.52 (0.43–0.63); 0.36 (0.27–0.48)	0.66 (0.52–0.84); 0.32 (0.21–0.5);	0.53 (0.42–0.68); 0.40 (0.34–0.46)
	p = 0.003	p = 0.0009	p < 0.0001	p = 0.02	p = 0.004	p = 0.03

p values represent IC₅₀ comparisons between wild type and EGFRvIII + cells. Initial numbers represent the mean IC₅₀ and 95% confidence intervals for wild type cells (either 897 or D54), the latter the mean IC₅₀ and 95% confidence intervals for EGFRvIII + cells (either 898 or D54E). Each individual experiment was performed in sextuplicate

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