Table 1 Pituitary weight, serum prolactin and estrogen levels in the three experimental models of prolactinomas.
Pituitary weight (mg) | P < | serum prolactin (ng/ml) | P < | serum estrogens | |
|---|---|---|---|---|---|
Wildtype mouse | 2.51 ± 0.34 | 0.001 | 29.1 ± 6.6 | 0.001 | normal |
D2R KO mouse | 7.03 ± 1.39 | 272.8 ± 59.7 | low | ||
Young rat | 11.3 ± 0.5 | 0.01 | 24.3 ± 3.2 | 0.01 | 28.9 ± 2.6 pg/ml |
Senile rat | 20.2 ± 6.2 | 98.3 ± 20.8 | 36.5 ± 1.8 pg/ml | ||
Control oil- injected rat | 14.7 ± 0.3 | 0.001 | 9.4 ± 1.7 | 0.001 | normal |
DES injected rat | 43.6 ± 3.7 | 444.0 ± 41.7 | high |