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Figure 3 | Molecular Cancer

Figure 3

From: In vivo optical imaging of integrin αV3 in mice using multivalent or monovalent cRGD targeting vectors

Figure 3

(a) Representative fluorescence images of Swiss nude mice bearing HEK293(β1) or HEK293(β3) s.c. tumors after i.v. injection of 10 nmol Cy5-labeled RAFT-c(-RGDfK-)4, cRGD, or RAFT-c(-RβADfK)4. All images were displayed at the indicated LUT (look-up-table) value. The values shown in each image represent the range of minimal to maximum signal intensity. T and K indicate tumor and kidney, respectively. (b) Time-courses of fluorescence intensities in tumors and skin as well as ratios of tumor vs. skin after i.v. injection of 10 nmol Cy5-labeled RAFT-c(-RGDfK-)4, cRGD, or RAFT-c(-RβADfK-)4. Solid circles: HEK293(β3) + Cy5-RAFT-c(-RGDfK-)4; Solid squares: HEK293(β3) + Cy5-cRGD; Solid triangles: HEK293(β3) + Cy5-RAFT-c(-RβADfK-)4; Open circles: HEK293(β1) + Cy5-RAFT-c(-RGDfK-)4. The fluorescence intensity was recorded as photons per pixel for a specified ROI. Data are expressed as means ± SD (n = 3–4).

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