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Figure 3 | Molecular Cancer

Figure 3

From: DNA methylation profiling of ovarian carcinomas and their in vitro models identifies HOXA9, HOXB5, SCGB3A1, and CRABP1 as novel targets

Figure 3

Direct bisulphite sequencing verified methylation status as assessed by methylation-specific polymerase chain reaction (MSP). Methylation status of individual CpG sites in HOXA9 (a), SCGB3A1 (b), and CRABP1 (c). The upper panel of each gene shows the CpG sites (vertical bars) amplified by the bisulphite sequencing primers. Bent arrows indicate the location of the MSP primers, whereas straight arrows indicate the transcription start site of individual genes. Black filled circles represent methylated CpGs; Open circles represent unmethylated CpGs; Gray circles represent partial methylation, defined as 21–80% methylation. The column at the right side of each panel (U, M, and U/M) shows the methylation status as assessed by MSP analysis.

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Molecular Cancer

ISSN: 1476-4598