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Table 1 Methylation correlated with clinical features in ovarian carcinomas

From: DNA methylation profiling of ovarian carcinomas and their in vitro models identifies HOXA9, HOXB5, SCGB3A1, and CRABP1 as novel targets

 

APC

CDH13

CRABP1

HOXA9

HOXB5

MLH1

RASSF1A

SCGB3A1

Age group

        

<60 years

6/29

6/30

0/29

11/30

2/30

1/30

15/26

1/30

> = 60 years

6/22

4/21

2/19

15/21

4/22

0/21

8/21

4/22

P value

NS

NS

NS

0.023

NS

NS

NS

NS

FIGO stage

        

IA-IIC

9/25

7/24

2/24

18/24

2/25

1/24

14/23

5/25

III-IV

3/26

3/27

0/24

8/27

4/27

0/27

9/24

0/27

P value

0.052

NS

NS

0.002

NS

NS

NS

0.020

Histological Type

        

Serous

3/19

1/19

0/19

4/19

2/19

0/19

8/19

0/19

Mucous

3/5

1/4

0/4

3/4

0/5

0/4

2/5

3/5

Clear cell

3/5

3/5

2/3

4/5

1/5

0/5

4/5

2/5

Endometrioid

3/17

3/17

0/16

12/17

2/17

1/17

7/14

0/17

P value

NS

0.041

<0.001

0.007

NS

NS

NS

<0.001

Grade of differentiation

        

Poorly

5/23

4/23

2/21

11/23

3/23

0/23

8/22

2/23

Moderate

3/14

4/15

0/14

9/15

3/15

1/15

10/13

0/15

Well

4/12

1/11

0/11

5/11

0/12

0/11

4/10

3/12

P value

NS

NS

NS

NS

NS

NS

0.055

0.095

  1. Abbreviations: NS, no significance; P values are two-sided and considered statistically significant when P <= 0.05. The table is based on 52 primary carcinomas from 50 patients.