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Figure 1 | Molecular Cancer

Figure 1

From: Cytotoxic effect of 5-aminoimidazole-4-carboxamide-1-β-4-ribofuranoside (AICAR) on childhood acute lymphoblastic leukemia (ALL) cells: implication for targeted therapy

Figure 1

AICAR treatment inhibits proliferation of human childhood leukemia ALL cells. The ALL cell lines CCRF-CEM (T-lineage), NALM6 (Bp-lineage), REH (Bp-ALL expressing the TEL/AML1 fusion protein), and SupB15 (Bp-ALL expressing the BCR/ABL fusion protein) were treated for 24 h with various concentrations of AICAR (0.25 – 2 mM), and cell growth analyzed by thymidine ribotide ([3H]TdR) incorporation into DNA. The results are expressed as percentage of [3H]thymidine uptake (%) relative to control values (mean ± SEM, n = 3). #, p < 0.001 for AICAR-treated cells vs. control.

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Molecular Cancer

ISSN: 1476-4598