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Table 1 Association of Hsp27 phosphorylation with HER-2/neu status and lymph node positivity

From: Phosphorylation of Ser78 of Hsp27 correlated with HER-2/neu status and lymph node positivity in breast cancer

  HER-2/neu statusb Lymph node
Intensitya Positive (n = 21) Negative (n = 68) p Positive (n = 36) Negative (n = 53) p
pSer78       
N 2 30   8 24  
P 19 38 0.004 28 29 0.026
pSer82       
N 8 40   20 28  
P 13 28 0.096 16 25 0.800
pSer15       
N 15 53   26 42  
P 6 15 0.539 10 11 0.444
Hsp27       
N 3 26   13 16  
P 18 42 0.041 23 37 0.558
  1. astaining level was defined as negative for negative/weak staining and positive for moderate and strong staining. P: positive; N: negative. bHER-2/neu status was described based on FISH: the cutoff value for positive is ≥ 2:1 (HER-2 locus: CEP-17). p value was calculated from the chi-square test. Significance was set at p < 0.05.