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Table 1 Association of Hsp27 phosphorylation with HER-2/neu status and lymph node positivity

From: Phosphorylation of Ser78 of Hsp27 correlated with HER-2/neu status and lymph node positivity in breast cancer

 

HER-2/neu statusb

Lymph node

Intensitya

Positive (n = 21)

Negative (n = 68)

p

Positive (n = 36)

Negative (n = 53)

p

pSer78

      

N

2

30

 

8

24

 

P

19

38

0.004

28

29

0.026

pSer82

      

N

8

40

 

20

28

 

P

13

28

0.096

16

25

0.800

pSer15

      

N

15

53

 

26

42

 

P

6

15

0.539

10

11

0.444

Hsp27

      

N

3

26

 

13

16

 

P

18

42

0.041

23

37

0.558

  1. astaining level was defined as negative for negative/weak staining and positive for moderate and strong staining. P: positive; N: negative. bHER-2/neu status was described based on FISH: the cutoff value for positive is ≥ 2:1 (HER-2 locus: CEP-17). p value was calculated from the chi-square test. Significance was set at p < 0.05.
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Molecular Cancer

ISSN: 1476-4598