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Table 2 List of SAM-identified genes (n = 40) predicted as target for hsa-mir-372 and 373

From: Molecular portrait of cisplatin induced response in human testis cancer cell lines based on gene expression profiles

UniGene ID Gene Name Description SAM score(d)
A) 24 miR-372&373 target genes that are up-regulated in TGCT cells and down-regulated in HCT116 cells
UniGene ID Gene_symbol Gene_description Score(d)
Hs.280604 PPP3R1 Protein phosphatase 3 (formerly 2B), regulatory subunit B, 19 kDa, alpha isoform 6.48
Hs.201034 NTN4 Netrin 4 6.35
Hs.126497 AEBP2 AE binding protein 2 6.18
Hs.373857 KLF12 Kruppel-like factor 12 6.06
Hs.514242 PLEKHM1 Pleckstrin homology domain containing, family M (with RUN domain) member 1 5.93
Hs.499489 MARCH8 Membrane-associated ring finger (C3HC4) 8 5.63
Hs.349150 PURB Purine-rich element binding protein B 5.55
Hs.25960 MYCN V-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 5.25
Hs.474536 MTMR3 Myotubularin related protein 3 5.24
Hs.291623 TAOK2 TAO kinase 2 5.24
Hs.271341 RABGAP1 RAB GTPase activating protein 1 5.13
Hs.134221 MBNL2 Muscleblind-like 2 (Drosophila) 4.92
Hs.520187 PYCR2 Pyrroline-5-carboxylate reductase family, member 2 4.78
Hs.490347 MKRN1 Makorin, ring finger protein, 1 4.75
Hs.191179 RAB11FIP1 RAB11 family interacting protein 1 (class I) 4.67
Hs.567754 MIER3 Mesoderm induction early response 1, family member 3 4.48
Hs.4779 GATAD2B GATA zinc finger domain containing 2B 4.34
Hs.159430 FNDC3B Fibronectin type III domain containing 3B 4.20
Hs.632239 MNT MAX binding protein 4.16
Hs.591552 RAB6A RAB6A, member RAS oncogene family 4.15
Hs.434961 ATXN1 Ataxin 1 4.06
Hs.149261 RUNX1 Runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene) 3.69
Hs.497148 RGL1 Ral guanine nucleotide dissociation stimulator-like 1 3.19
Hs.208124 ESR1* Estrogen receptor 1 3.04
B) 16 miR-372&373 target genes that are down-regulated in TGCT cells and up-regulated in HCT116 cells
Hs.293798 ZNF436 Zinc finger protein 436 -7.05
Hs.388613 NEO1* Neogenin homolog 1 (chicken) -7.00
Hs.374097 IRF2 Interferon regulatory factor 2 -6.13
Hs.122927 RSNL2 Restin-like 2 -6.09
Hs.514308 FAM117A Family with sequence similarity 117, member A -5.92
Hs.444213 TLE4 Transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) -5.92
Hs.428027 PBX3 Pre-B-cell leukemia transcription factor 3 -5.78
Hs.511316 GABPB2 GA binding protein transcription factor, beta subunit 2 -5.52
Hs.529044 RAB22A RAB22A, member RAS oncogene family -5.45
Hs.434993 RBJ Ras-associated protein Rap1 -5.28
Hs.496138 IQSEC2 IQ motif and Sec7 domain 2 -4.70
Hs.78960 LATS2* LATS, large tumor suppressor, homolog 2 (Drosophila) -4.54
Hs.269592 CC2D1A Coiled-coil and C2 domain containing 1A -4.21
Hs.521083 HRBL HIV-1 Rev binding protein-like -4.19
Hs.469658 BCL2L11 BCL2-like 11 (apoptosis facilitator) -4.08
Hs.299315 DPYSL5 Dihydropyrimidinase-like 5 -3.93
  1. NEO1, LATS2 and ESR1 are the only target genes in common for both p53 and hsa-mir-372 and -373.