Table 2 List of SAM-identified genes (n = 40) predicted as target for hsa-mir-372 and 373
UniGene ID | Gene Name | Description | SAM score(d) |
|---|---|---|---|
A) 24 miR-372&373 target genes that are up-regulated in TGCT cells and down-regulated in HCT116 cells | |||
UniGene ID | Gene_symbol | Gene_description | Score(d) |
Hs.280604 | PPP3R1 | Protein phosphatase 3 (formerly 2B), regulatory subunit B, 19 kDa, alpha isoform | 6.48 |
Hs.201034 | NTN4 | Netrin 4 | 6.35 |
Hs.126497 | AEBP2 | AE binding protein 2 | 6.18 |
Hs.373857 | KLF12 | Kruppel-like factor 12 | 6.06 |
Hs.514242 | PLEKHM1 | Pleckstrin homology domain containing, family M (with RUN domain) member 1 | 5.93 |
Hs.499489 | MARCH8 | Membrane-associated ring finger (C3HC4) 8 | 5.63 |
Hs.349150 | PURB | Purine-rich element binding protein B | 5.55 |
Hs.25960 | MYCN | V-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) | 5.25 |
Hs.474536 | MTMR3 | Myotubularin related protein 3 | 5.24 |
Hs.291623 | TAOK2 | TAO kinase 2 | 5.24 |
Hs.271341 | RABGAP1 | RAB GTPase activating protein 1 | 5.13 |
Hs.134221 | MBNL2 | Muscleblind-like 2 (Drosophila) | 4.92 |
Hs.520187 | PYCR2 | Pyrroline-5-carboxylate reductase family, member 2 | 4.78 |
Hs.490347 | MKRN1 | Makorin, ring finger protein, 1 | 4.75 |
Hs.191179 | RAB11FIP1 | RAB11 family interacting protein 1 (class I) | 4.67 |
Hs.567754 | MIER3 | Mesoderm induction early response 1, family member 3 | 4.48 |
Hs.4779 | GATAD2B | GATA zinc finger domain containing 2B | 4.34 |
Hs.159430 | FNDC3B | Fibronectin type III domain containing 3B | 4.20 |
Hs.632239 | MNT | MAX binding protein | 4.16 |
Hs.591552 | RAB6A | RAB6A, member RAS oncogene family | 4.15 |
Hs.434961 | ATXN1 | Ataxin 1 | 4.06 |
Hs.149261 | RUNX1 | Runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene) | 3.69 |
Hs.497148 | RGL1 | Ral guanine nucleotide dissociation stimulator-like 1 | 3.19 |
Hs.208124 | ESR1* | Estrogen receptor 1 | 3.04 |
B) 16 miR-372&373 target genes that are down-regulated in TGCT cells and up-regulated in HCT116 cells | |||
Hs.293798 | ZNF436 | Zinc finger protein 436 | -7.05 |
Hs.388613 | NEO1* | Neogenin homolog 1 (chicken) | -7.00 |
Hs.374097 | IRF2 | Interferon regulatory factor 2 | -6.13 |
Hs.122927 | RSNL2 | Restin-like 2 | -6.09 |
Hs.514308 | FAM117A | Family with sequence similarity 117, member A | -5.92 |
Hs.444213 | TLE4 | Transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) | -5.92 |
Hs.428027 | PBX3 | Pre-B-cell leukemia transcription factor 3 | -5.78 |
Hs.511316 | GABPB2 | GA binding protein transcription factor, beta subunit 2 | -5.52 |
Hs.529044 | RAB22A | RAB22A, member RAS oncogene family | -5.45 |
Hs.434993 | RBJ | Ras-associated protein Rap1 | -5.28 |
Hs.496138 | IQSEC2 | IQ motif and Sec7 domain 2 | -4.70 |
Hs.78960 | LATS2* | LATS, large tumor suppressor, homolog 2 (Drosophila) | -4.54 |
Hs.269592 | CC2D1A | Coiled-coil and C2 domain containing 1A | -4.21 |
Hs.521083 | HRBL | HIV-1 Rev binding protein-like | -4.19 |
Hs.469658 | BCL2L11 | BCL2-like 11 (apoptosis facilitator) | -4.08 |
Hs.299315 | DPYSL5 | Dihydropyrimidinase-like 5 | -3.93 |