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Table 3 List of apoptosis-related genes (n = 24). 15 up-regulated and 9 down-regulated genes in TGCT cells following cisplatin exposure

From: Molecular portrait of cisplatin induced response in human testis cancer cell lines based on gene expression profiles

UniGene ID Gene Name Description SAM Score(d) Function
A) 15 apoptosis-related genes that are up-regulated in TGCT cells and down-regulated in HCT116 cells
Hs.1722 IL1A Interleukin 1, alpha 8.62 anti-apoptosis
Hs.283672 BCL2L10 BCL2-like 10 (apoptosis facilitator) 8.03 anti-apoptosis
Hs.631672 BCL2L13 BCL2-like 13 (apoptosis facilitator) 6.51 Regulation of apoptosis
Hs.458272 MPO Myeloperoxidase 5.96 anti-apoptosis
Hs.303649 CCL2 Chemokine (C-C motif) ligand 2 5.78 anti-apoptosis
Hs.591630 CASP8 Caspase 8, apoptosis-related cysteine peptidase 5.04 apoptotic program
Hs.89679 IL2 Interleukin 2 5.02 anti-apoptosis
Hs.200242 CARD6 Caspase recruitment domain family, member 6 4.83 regulation of apoptosis
Hs.160953 P53AIP1 P53-regulated apoptosis-inducing protein 1 4.65 apoptosis
Hs.5443 BAG5 BCL2-associated athanogene 5 4.57 anti-apoptosis
Hs.350899 CAPN2 Calpain 2, (m/II) large subunit 4.45 proteolysis and peptidolysis
Hs.159195 DOCK1 Dedicator of cytokinesis 1 4.33 Apoptosis
Hs.521800 CAPN1 Calpain 1, (mu/I) large subunit 3.97 proteolysis and peptidolysis
Hs.88297 STK17B Serine/threonine kinase 17b (apoptosis-inducing) 3.62 apoptosis
Hs.545196 GML GPI anchored molecule like protein 3.41 apoptosis
B) 9 apoptosis-related genes that are down-regulated in TGCT cells and up-regulated in HCT116 cells
Hs.194726 BAG4 BCL2-associated athanogene 4 -6.33 anti-apoptosis
Hs.256126 BIRC7 Baculoviral IAP repeat-containing 7 (livin) -5.59 anti-apoptosis
Hs.102402 MXD4 MAX dimerization protein 4 -5.59 negative regulation of cell proliferation
Hs.412311 APITD1 Apoptosis-inducing, TAF9-like domain 1 -5.23 arole in a cell death pathway
Hs.107153 ING2 Inhibitor of growth family, member 2 -5.07 P53-dependent apoptotic pathways
Hs.643130 PAWR PRKC, apoptosis, WT1, regulator -4.99 apoptosis
Hs.379186 PDCD6 Programmed cell death 6 -4.79 Induction of apoptosis
Hs.271955 TNFAIP8 Tumor necrosis factor, alpha-induced protein 8 -4.46 anti-apoptosis
Hs.469658 BCL2L11 BCL2-like 11 (apoptosis facilitator) -4.08 apoptosis