Table 3 List of apoptosis-related genes (n = 24). 15 up-regulated and 9 down-regulated genes in TGCT cells following cisplatin exposure
UniGene ID | Gene Name | Description | SAM Score(d) | Function |
|---|---|---|---|---|
A) 15 apoptosis-related genes that are up-regulated in TGCT cells and down-regulated in HCT116 cells | ||||
Hs.1722 | IL1A | Interleukin 1, alpha | 8.62 | anti-apoptosis |
Hs.283672 | BCL2L10 | BCL2-like 10 (apoptosis facilitator) | 8.03 | anti-apoptosis |
Hs.631672 | BCL2L13 | BCL2-like 13 (apoptosis facilitator) | 6.51 | Regulation of apoptosis |
Hs.458272 | MPO | Myeloperoxidase | 5.96 | anti-apoptosis |
Hs.303649 | CCL2 | Chemokine (C-C motif) ligand 2 | 5.78 | anti-apoptosis |
Hs.591630 | CASP8 | Caspase 8, apoptosis-related cysteine peptidase | 5.04 | apoptotic program |
Hs.89679 | IL2 | Interleukin 2 | 5.02 | anti-apoptosis |
Hs.200242 | CARD6 | Caspase recruitment domain family, member 6 | 4.83 | regulation of apoptosis |
Hs.160953 | P53AIP1 | P53-regulated apoptosis-inducing protein 1 | 4.65 | apoptosis |
Hs.5443 | BAG5 | BCL2-associated athanogene 5 | 4.57 | anti-apoptosis |
Hs.350899 | CAPN2 | Calpain 2, (m/II) large subunit | 4.45 | proteolysis and peptidolysis |
Hs.159195 | DOCK1 | Dedicator of cytokinesis 1 | 4.33 | Apoptosis |
Hs.521800 | CAPN1 | Calpain 1, (mu/I) large subunit | 3.97 | proteolysis and peptidolysis |
Hs.88297 | STK17B | Serine/threonine kinase 17b (apoptosis-inducing) | 3.62 | apoptosis |
Hs.545196 | GML | GPI anchored molecule like protein | 3.41 | apoptosis |
B) 9 apoptosis-related genes that are down-regulated in TGCT cells and up-regulated in HCT116 cells | ||||
Hs.194726 | BAG4 | BCL2-associated athanogene 4 | -6.33 | anti-apoptosis |
Hs.256126 | BIRC7 | Baculoviral IAP repeat-containing 7 (livin) | -5.59 | anti-apoptosis |
Hs.102402 | MXD4 | MAX dimerization protein 4 | -5.59 | negative regulation of cell proliferation |
Hs.412311 | APITD1 | Apoptosis-inducing, TAF9-like domain 1 | -5.23 | arole in a cell death pathway |
Hs.107153 | ING2 | Inhibitor of growth family, member 2 | -5.07 | P53-dependent apoptotic pathways |
Hs.643130 | PAWR | PRKC, apoptosis, WT1, regulator | -4.99 | apoptosis |
Hs.379186 | PDCD6 | Programmed cell death 6 | -4.79 | Induction of apoptosis |
Hs.271955 | TNFAIP8 | Tumor necrosis factor, alpha-induced protein 8 | -4.46 | anti-apoptosis |
Hs.469658 | BCL2L11 | BCL2-like 11 (apoptosis facilitator) | -4.08 | apoptosis |