Table 1 Clinical and bio-pathological features of colorectal carcinomas employed in the study.
From: mRNA/microRNA gene expression profile in microsatellite unstable colorectal cancer
Feature | No. | MSS | (%) | MSI-H | (%) | P-value* |
|---|---|---|---|---|---|---|
Sex | ||||||
Male | 21 | 15 | (65.2) | 6 | (37.5) | NS |
Female | 18 | 8 | (34.8) | 10 | (62.5) | |
Age (years) | ||||||
<55 | 3 | 2 | (8.7) | 1 | (6.3) | NS |
55–70 | 11 | 9 | (39.1) | 2 | (12.5) | |
>70 | 25 | 12 | (52.2) | 13 | (81.3) | |
Tumor site | ||||||
Proximal colon | 18 | 5 | (21.7) | 13 | (81.3) | <0.001 |
Distal colon | 21 | 18 | (78.3) | 3 | (18.7) | |
Tumor stage (TNM) | ||||||
I | 2 | 1 | (4.3) | 1 | (6.3) | NS |
II | 16 | 9 | (39.2) | 7 | (43.8) | |
III | 13 | 7 | (30.4) | 6 | (37.5) | |
IV | 8 | 6 | (26.1) | 2 | (12.5) | |
Tumor type | ||||||
Adenocarcinoma | 29 | 22 | (95.7) | 7 | (43.7) | <0.001 |
Mucinous adenocarcinoma | 10 | 1 | (4.3) | 9 | (56.3) | |
Grade of differentiation | ||||||
Well/moderate | 29 | 22 | (95.7) | 7 | (43.7) | <0.001 |
Poor | 10 | 1 | (4.3) | 9 | (56.3) | |
MMR protein expression | ||||||
MLH1 negative | 15 | 0 | 15 | (93.8) | <0,001 | |
MSH2 negative | 1 | 0 | 1 | (6.2) | ||
MLH1/MSH2 positive | 23 | 23 | (100) | 0 |