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Table 1 Clinical and bio-pathological features of colorectal carcinomas employed in the study.

From: mRNA/microRNA gene expression profile in microsatellite unstable colorectal cancer

Feature No. MSS (%) MSI-H (%) P-value*
Sex       
   Male 21 15 (65.2) 6 (37.5) NS
   Female 18 8 (34.8) 10 (62.5)  
Age (years)       
   <55 3 2 (8.7) 1 (6.3) NS
   55–70 11 9 (39.1) 2 (12.5)  
   >70 25 12 (52.2) 13 (81.3)  
Tumor site       
   Proximal colon 18 5 (21.7) 13 (81.3) <0.001
   Distal colon 21 18 (78.3) 3 (18.7)  
Tumor stage (TNM)       
   I 2 1 (4.3) 1 (6.3) NS
   II 16 9 (39.2) 7 (43.8)  
   III 13 7 (30.4) 6 (37.5)  
   IV 8 6 (26.1) 2 (12.5)  
Tumor type       
   Adenocarcinoma 29 22 (95.7) 7 (43.7) <0.001
   Mucinous adenocarcinoma 10 1 (4.3) 9 (56.3)  
Grade of differentiation       
   Well/moderate 29 22 (95.7) 7 (43.7) <0.001
   Poor 10 1 (4.3) 9 (56.3)  
MMR protein expression       
   MLH1 negative 15 0   15 (93.8) <0,001
   MSH2 negative 1 0   1 (6.2)  
   MLH1/MSH2 positive 23 23 (100) 0   
  1. * Evaluated with Chi-square test or the Fisher's Exact test
  2. NS, not significant