Table 2 Predictors of microsatellite status identified by Support Vector Machine and PAM algorithms.
From: mRNA/microRNA gene expression profile in microsatellite unstable colorectal cancer
Probe | Symbol | Average expression | p-value | SVM* strength | PAM* score | |||
|---|---|---|---|---|---|---|---|---|
Gene name | MSS | MSI-H | MSI-H | MSS | ||||
hsa-mir-223-prec | miR-223 | 0.97 | 1.84 | 4.69E-02 | - | 0.4929 | -0.3429 | |
hsa-mir-155-prec | miR-155 (BIC) | 0.97 | 1.29 | 2.34E-02 | - | 0.4439 | -0.3088 | |
AL137343 | FAM84A | family with sequence similarity 84, member A | 1.51 | 0.45 | 1.07E-02 | - | -0.0208 | 0.0145 |
NM_004183 | VMD2 | vitelliform macular dystrophy 2 | 2.09 | 0.38 | 8.73E-03 | - | -0.1832 | 0.1274 |
NM_006113 | VAV3 | vav 3 oncogene | 1.62 | 0.47 | 5.98E-03 | 13.96 | -0.0533 | 0.0371 |
NM_005953 | MT2A | metallothionein 2A | 0.57 | 1.92 | 5.93E-03 | 16.34 | 0.8995 | -0.6258 |
AK026372 | KIAA1718 | 1.27 | 0.72 | 5.09E-03 | 16.02 | - | - | |
hsa-mir-191-prec | miR-191 | 1.28 | 1.00 | 4.74E-03 | - | 0.0377 | -0.0263 | |
NM_017726 | PPP1R14D | protein phosphatase 1, regulatory (inhibitor) subunit 14D | 1.31 | 0.52 | 3.88E-03 | 14.58 | - | - |
NM_003212 | TDGF1 | teratocarcinoma-derived growth factor 1 | 1.49 | 0.76 | 3.37E-03 | 16.49 | - | - |
AF273051 | CCDC68 | coiled-coil domain containing 68 | 2.21 | 0.84 | 2.49E-03 | 15.87 | -0.0541 | 0.0376 |
NM_016328 | GTF2IRD1 | GTF2I repeat domain containing 1 | 1.49 | 0.87 | 2.13E-03 | 13.13 | - | - |
NM_001657 | AREG | amphiregulin | 2.10 | 0.69 | 1.04E-03 | - | -0.0725 | 0.0504 |
AB033045 | KIAA1219 | hypothetical protein LOC57148 | 1.33 | 0.83 | 8.11E-04 | 15.87 | - | - |
hsa-mir-032-precNo2 | miR-032 | 1.17 | 0.91 | 6.48E-04 | 14.02 | 0.0732 | -0.0509 | |
NM_004485 | GNG4 | guanine nucleotide binding protein (G protein), gamma 4 | 1.46 | 0.81 | 6.47E-04 | 16.49 | - | - |
NM_018267 | H2AFJ | H2A histone family, member J | 1.43 | 0.92 | 6.47E-04 | 13.96 | - | - |
AK000276 | NKD1 | naked cuticle homolog 1 | 2.47 | 0.77 | 4.55E-04 | 17.48 | -0.1542 | 0.1072 |
NM_003878 | GGH | gamma-glutamyl hydrolase | 2.10 | 0.61 | 7.97E-05 | 15.87 | -0.2232 | 0.1553 |
AK025215 | C13ORF18 | chromosome 13 open reading frame 18 | 2.41 | 0.66 | 4.40E-05 | 16.49 | -0.3093 | 0.2152 |
NM_017763 | RNF43 | ring finger protein 43 | 2.10 | 0.57 | 2.91E-05 | 17.48 | -0.2886 | 0.2008 |
NM_004693 | K6HF | cytokeratin type II | 1.24 | 0.80 | 2.91E-05 | 14.6 | - | - |
NM_002657 | PLAGL2 | pleiomorphic adenoma gene-like 2 | 1.37 | 0.76 | 2.91E-05 | 19.32 | - | - |
hsa-mir-025-prec | miR-025 | 1.52 | 0.84 | 2.14E-05 | 17.48 | - | - | |
hsa-mir-092-prec-13=092-1No2 | miR-092-1 | 1.50 | 0.65 | 1.87E-05 | 17.48 | - | - | |
hsa-mir-092-prec-X=092-2 | miR-092-2 | 1.60 | 0.64 | 1.87E-05 | 14.43 | - | - | |
hsa-mir-093-prec-7.1=093-1 | miR-093-1 | 1.23 | 0.9 | 1.87E-05 | - | 0.0084 | -0.0058 | |