Figure 2
From: Nuclear localization of beta-catenin involved in precancerous change in oral leukoplakia
Comparison of immunohistochemical staining for β-catenin, Wnt3, cyclin D1, and c-myc in oral leukoplakia. (a-d) Serial sections of oral leukoplakia without dysplasia. (a) Nuclear expression of β-catenin was not observed. (b) Wnt3 expression was not observed. (c) Cyclin D1 shows weak expression. (d) Nuclear expression of c-myc is observed in the basal layer cells. (e-h) Serial sections of oral leukoplakia with dysplasia. (e, i) β-Catenin is expressed in the nuclei. (f, j) Wnt3 expression is observed on the epithelial cell membrane and in the cytoplasm. (g, k) Cyclin D1 is expressed in several epithelial cells. (h, l) c-Myc shows similar expression pattern as oral leukoplakia without dysplasia. Scale bars: (a-h) 100 μm; (i-l) 50 μm.