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Table 1 Histopathological Characteristics of Meningioma Tumors

From: Molecular signatures define two main classes of meningiomas

 

SF4271

SF4287

SF4316

SF4465

SF4881

SF4886

SF4894

SF4931

SF3072

SF3118

SF3363

SF3411

SF4151

SF2176

SF3622

SF2841

SF3476

SF3595

SF3693

SF3938

SF4005

SF4290

SF4457

Grade

BENIGN (GRADE 1)

ATYPICAL (GRADE 2)

MALIGNANT (GRADE 3)

Molecular Subgroup

LOW-PROLIFERATIVE

*

HIGH-PROLIFERATIVE

Embolized

No

Y

Y

No

No

No

No

Y

No

Y

No

Y

No

No

No

Y

Y

No

N

Y

Y

Y

No

Histological Subtype

M

T

M

M

Fi

T

T

T

     

CC

         

Mitotic Index

N

N

N

N

N

E/F

E/F

N

N

N

N

N

E/F

N

E/F

E

E/F

E

E

E

E

E

E

Increased Cellularity

E/F

N

N

N

N

N

E/F

N

N

E/F

E/F

E

E/F

E

E

E

E

E

E

E

E

E

E

Nuclear/Cytoplasmic Ratio

E/F

N

E/F

N

N

E/F

E/F

N

E

E

E

E

N

E/F

E/F

E

F

E

E

E

E

E

E

Prominent Nucleoli

E/F

N

E/F

N

N

E/F

E/F

N

E

E

E

E

N

E/F

E/F

E

F

E

E

E

E

E

E

Cellular Pattern Loss

E/F

N

N

N

N

N

E/F

N

N

E/F

E/F

E

E/F

E

E

E

E/F

E

E

E

E

E

E

Necrosis

E/F

E/F

E/F

N

N

N

N

N

N

N

N

E

N

N

E

E

E

E

E/F

E

E

E

E

Brain Invasion

        

Y

      

Y

    

Y

  

MIB-1

1.5

1.6

2.0

0.9

0.8

0.1

1.3

1.9

5.9

4.2

3.7

7.0

7.0

7.7

8.5

10.9

11.3

17.5

20.3

16.9

7.5

7.5

23.3

  1. No = No; Y = Yes; M = Meningothelial; T = Transitional; Fi = Fibroblastic; CC = Clear Cell Characteristics N = Not Elevated or Absent; E = Elevated; F = Focal; §E indicates a mitotic index of >4 mitosis/10 high powered field while N indicates <4 mitosis/10 high powered field; * Refers to the Grade 2 meningioma that was an outlier
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Molecular Cancer

ISSN: 1476-4598