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Figure 3 | Molecular Cancer

Figure 3

From: Role of PP2Cα in cell growth, in radio- and chemosensitivity, and in tumorigenicity

Figure 3

Evaluation of the chemosensitivity of wild type and PP2Cα siRNA-expressing MCF7 cells. A and B: Effect of different doses of doxorubicin on the proliferation of MCF7-wt and MCF7-si cells. The cells were either exposed to the drug for 24 h (A) or continuously (B). Values represent average ± SD (n = 3). C: Effect of doxorubicin on the clonogenicity of MCF7-wt and MCF7-si cells. Values represent average ± SD (n = 3). D: Effect of gemcitabine on the clonogenicity of MCF7-wt and MCF7-si cells. Values represent average ± SD (n = 3). E and F: Quantification of the effect of doxorubicin on the viability (i.e. the membrane integrity) of MCF7-wt and MCF7-si cells. The viability was determined by means of FACS analysis. Values represent average ± SD (n = 3). G: Representative images of the cell cycle distribution of MCF7-wt and MCF7-si cells after 48 h of doxorubicin treatment.

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