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Figure 4 | Molecular Cancer

Figure 4

From: Transcriptional changes associated with breast cancer occur as normal human mammary epithelial cells overcome senescence barriers and become immortalized

Figure 4

Supervised Clustering of Pre-stasis, Post-selection and Immortalized HMEC. A. Gene expression values were normalized and characterized for the significance of over-expression in one group relative to other groups in the comparison. The top 200 genes (of 1342) that are significantly over-expressed in one group are shown. All pre-stasis, post-selection and immortalized HMEC (except the p53-/- and ERBB2/Her2 transfected variants) have been grouped. The top 100 genes (of 1440) that are over-expressed in one group relative to the other two are presented. Analysis was performed in GeneCluster. B. Expression of a subset of highly concordant genes in pre-stasis, post-selection and fully immortalized HMEC. Gene-normalized expression of 60 genes identified in the figure are shown for four representatives each for the three groups of HMEC. Samples are (left to right): 48L, 161, 195L and 184; 48R, 161, 195L, and 184; 184A1, 184B5, MCF-10A and MCF12A.

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