Two-dimensional hierarchical clustering of samples and loci based on DNA methylation data. In the center, DNA methylation levels are indicated by a color gradient, with the highest DNA methylation levels for each locus indicated in red and the lowest in deep blue. The Ward hierarchical clustering method was used to categorize between cancer and non-tumor samples. Sample IDs are indicated on the left, with AD samples in red, AdjNTL samples in black, and NTL samples in blue. The relationship of samples is indicated at right in the same color schematic as the labels. At bottom, the relationship of the loci is indicated. Note that all eight of the most significant loci cluster at bottom right.