Table 1 Gene name and function of the 28 loci studied
From: Identification of a panel of sensitive and specific DNA methylation markers for lung adenocarcinoma
HUGO acronyma | Gene Nameb | Functionc |
|---|---|---|
APC | adenomatosis polyposis coli | Tumor suppressor. |
ATM | ataxia telangiectasia mutated | Tumor suppressor. DNA damage and cell cycle control. |
CDH1 | cadherin 1, type 1, E-cadherin (epithelial) | Involved in cell-cell adhesions, mobility and proliferation. |
CDH13 | cadherin 13, H-cadherin (heart) | Cell-cell adhesions. |
CDKN2A EX2 | cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) | Tumor suppressor. Cell cycle control. Involved in proliferation and apoptosis. |
CDKN2B | cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) | Cell cycle control. |
CDX2 | caudal type homeobox transcription factor 2 | Transciptional regulation. Involved in differentiation. |
CHFR | checkpoint with forkhead and ring finger domains | Cell cycle control. Involved in signaling. |
CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | Electron transport pathway. Involved in development. |
ESR1 | estrogen receptor 1 | Nuclear hormone receptor. Involved in the regulation of gene expression and affect proliferation and differentiation. |
HMGA1 | high mobility group AT-hook 1 | Involved in the transcription regulation. |
HOXA1 | homeobox A1 | Transcription factor. Involved in development. |
LZTS1 | leucine zipper, putative tumor suppressor 1 | Involved in the regulation of cell growth. Cell cycle control and proliferation. May act as tumor suppressor. |
MGMT | O-6-methylguanine-DNA methyltransferase | DNA repair. |
MT1A, MT2A | metallothionein 1A, 2A | Bind heavy metals. |
OPCMLd | opioid binding protein/cell adhesion molecule-like | Involved in cell contact |
PGR | progesterone receptor | Involved in the regulation of gene expression and cellular proliferation and differentiation. |
PTEN | phosphatase and tensin homolog | Tumor suppressor. Involved in cell cycle progression and cell survival. Involved in cell migration and cell spreading. |
RASSF1 | Ras association (RalGDS/AF-6) domain family 1 | Potential tumor suppressor. Invovled in apoptosis, proliferation, cell cycle progression. |
SFRP1, SFRP4, SFRP5 | secreted frizzled-related protein 1, 4, 5 | Role in regulating cell growth and differentiation and proliferation. Involved in development. |
SLC6A20 | solute carrier family 6 (proline IMINO transporter), member 20 | Sodium- and chloride-dependent transporter. |
SOCS4 | suppressor of cytokine signaling 4 | Involved in signal transduction. |
SYK | spleen tyrosine kinase | Involved in B cell response. |
TWIST1 | twist homolog 1 (acrocephalosyndactyly 3; Saethre-Chotzen syndrome) (Drosophila) | Transcription factor. Involved in differentiation. |
VHL | von Hippel-Lindau tumor suppressor | Involved in transcriptional repression. |