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Table 1 Gene name and function of the 28 loci studied

From: Identification of a panel of sensitive and specific DNA methylation markers for lung adenocarcinoma

HUGO acronyma Gene Nameb Functionc
APC adenomatosis polyposis coli Tumor suppressor.
ATM ataxia telangiectasia mutated Tumor suppressor. DNA damage and cell cycle control.
CDH1 cadherin 1, type 1, E-cadherin (epithelial) Involved in cell-cell adhesions, mobility and proliferation.
CDH13 cadherin 13, H-cadherin (heart) Cell-cell adhesions.
CDKN2A EX2 cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) Tumor suppressor. Cell cycle control. Involved in proliferation and apoptosis.
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) Cell cycle control.
CDX2 caudal type homeobox transcription factor 2 Transciptional regulation. Involved in differentiation.
CHFR checkpoint with forkhead and ring finger domains Cell cycle control. Involved in signaling.
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 Electron transport pathway. Involved in development.
ESR1 estrogen receptor 1 Nuclear hormone receptor. Involved in the regulation of gene expression and affect proliferation and differentiation.
HMGA1 high mobility group AT-hook 1 Involved in the transcription regulation.
HOXA1 homeobox A1 Transcription factor. Involved in development.
LZTS1 leucine zipper, putative tumor suppressor 1 Involved in the regulation of cell growth. Cell cycle control and proliferation. May act as tumor suppressor.
MGMT O-6-methylguanine-DNA methyltransferase DNA repair.
MT1A, MT2A metallothionein 1A, 2A Bind heavy metals.
OPCMLd opioid binding protein/cell adhesion molecule-like Involved in cell contact
PGR progesterone receptor Involved in the regulation of gene expression and cellular proliferation and differentiation.
PTEN phosphatase and tensin homolog Tumor suppressor. Involved in cell cycle progression and cell survival. Involved in cell migration and cell spreading.
RASSF1 Ras association (RalGDS/AF-6) domain family 1 Potential tumor suppressor. Invovled in apoptosis, proliferation, cell cycle progression.
SFRP1, SFRP4, SFRP5 secreted frizzled-related protein 1, 4, 5 Role in regulating cell growth and differentiation and proliferation. Involved in development.
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20 Sodium- and chloride-dependent transporter.
SOCS4 suppressor of cytokine signaling 4 Involved in signal transduction.
SYK spleen tyrosine kinase Involved in B cell response.
TWIST1 twist homolog 1 (acrocephalosyndactyly 3; Saethre-Chotzen syndrome) (Drosophila) Transcription factor. Involved in differentiation.
VHL von Hippel-Lindau tumor suppressor Involved in transcriptional repression.
  1. aHuman Genome Organization nomenclature
  2. bApproved gene name from Human Genome Organization website http://www.genenames.org/
  3. cGene function from GeneCards website http://www.genecards.org/index.shtml
  4. dMethyLight amplicon also targets the HNT CpG island