The natural immunity is the first actor on stage in immune surveillance processes. With an inherited set of pattern recognition receptors on NK cells and with natural IgM antibodies it recognizes and destroys all invasive particles and all changes and modifications within an organism. Their targets are often conservative structures, in most cases carbohydrates. Phagocytic cells clean "the battle field" and transport the garbage to nearby lymphoid organs. Here, the decision is made whether a memory should be initiated or not. In cases of infectious particles, immunocompetent Th cells (T-helper cells) are stimulated by presenting to them non-self (viral) protein peptides together with self structures (MHC). In consequence highly specific Tk (T-killer cells) and B2 cells are generated. In case of cancer cells and carbo-epitopes, this dual recognition fails, because the phagocytic cells cannot present carbohydrat structures originally seen by the innate immunity. Peptides which are associated with carbohydrate structures are "self" structures and therefore, an education and memory does normally not occur.