Figure 2
Effect of all-trans retinoic acid on incorporation of 3H-thymidine in CAPAN-2 (top panel) and Hs766T (bottom panel) cells over 48 and 96 hours. Concentration-dependent inhibition of DNA synthesis was observed in both cells lines. Two-way ANOVA: Capan-2: Concentration effect F(3,16) = 576, P < 0.0001; Time effect F(1,16) = 2.62, P = 0.125; Interaction F(3,16) = 28.9, P < 0.0001; Hs766T: Concentration effect F(3,24) = 846, P < 0.0001; Time effect F(1,24) = 0.05, P = 0.817; Interaction F(3,24) = 57.0, P < 0.0001. Data are expressed as counts per minute (CPM), bars represent means ± SEM.