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Figure 3 | Molecular Cancer

Figure 3

From: Synthesis and biologic properties of hydrophilic sapphyrins, a new class of tumor-selective inhibitors of gene expression

Figure 3

Hierarchical clustering analysis of gene expression data from drug-treated A549 cell cultures. The dendrograms were generated based on average linkage hierarchical clustering of expression data from 422 probe tilings whose coefficient of variation was greater than 0.15 across all groups. Data from untreated (mannitol) and drug-treated [(sapphyrin PCI-2050 = 2050) or (actinomycin D = ActD)] A549 cultures are provided in triplicate using the noted concentrations. The relative expression levels (↑ = up-regulated, ↓ = down-regulated) of selected gene groupings in drug-treated versus control cells are provided on the right side of the figure. Note that this reflects relationships only within the subset of genes used for cluster analysis.

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Molecular Cancer

ISSN: 1476-4598