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Figure 4 | Molecular Cancer

Figure 4

From: Synthesis and biologic properties of hydrophilic sapphyrins, a new class of tumor-selective inhibitors of gene expression

Figure 4

Activity of sapphyrins in A549 tumor xenograft model. A, Median tumor volume (± SEM) over time in mice treated with control (5% mannitol) vehicle, cisplatin (4 mg/kg q.d. × 4 i.p.), PCI-2050 (10 μmol/kg qd × 2 i.v.), or PCI-2022 (20 μmol/kg qd × 2 i.v.). * p < 0.001. B, Log concentration of PCI-2022 and PCI-2050 in plasma (μM) or in kidney and tumor (nmol/g) over time is shown.

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