Synthesis and biologic properties of hydrophilic sapphyrins, a new class of tumor-selective inhibitors of gene expression

Wang, Zhong; Lecane, Philip S; Thiemann, Patricia; Fan, Qing; Cortez, Cecilia; Ma, Xuan; Tonev, Danielle; Miles, Dale; Naumovski, Louie; Miller, Richard A; Magda, Darren; Cho, Dong-Gyu; Sessler, Jonathan L; Pike, Brian L; Yeligar, Samantha M; Karaman, Mazen W; Hacia, Joseph G

doi:10.1186/1476-4598-6-9

Molecular Cancer

Table 1 Selected transcripts up-regulated by 1.25uM PCI-2050 but down-regulated by 5 ug/ml actinomycin D.

From: Synthesis and biologic properties of hydrophilic sapphyrins, a new class of tumor-selective inhibitors of gene expression

Type	Probe Set Id^a	Gene Title^b	Symbol	GeneID^c	FC PCI-2050^d	P^e	FC ActD^f	P^e
Transcriptional Repressor Activity	221230_s_at	AT rich interactive domain 4B	ARID4B	51742	1.76	0.0067	-6.83	0.0024
	231292_at	E1A-like inhibitor of differentiation 3	EID3	493861	5.51	0.0006	-3.84	0.0096
	203643_at	Ets2 repressor factor	ERF	2077	1.74	0.0014	-3.27	0.0023
	202484_s_at	methyl-CpG binding domain protein 2	MBD2	8932	1.50	0.0086	-1.62	0.0038
	220746_s_at	receptor associated protein 80	RAP80	51720	1.60	0.0025	-1.95	0.0026
	218166_s_at	remodeling and spacing factor 1	RSF1	51773	2.17	0.0028	-2.78	0.0040
	219682_s_at	T-box 3 (ulnar mammary syndrome)	TBX3	6926	1.76	0.0043	-4.19	0.0014
	214714_at	zinc finger protein 394	ZNF394	84124	1.70	0.0033	-3.18	0.0012
Chromatin Remodelling	208445_s_at	bromodomain adjacent to zinc finger domain, 1B	BAZ1B	9031	1.62	0.0017	-2.22	0.0015
	208686_s_at	bromodomain containing 2	BRD2	6046	2.35	0.0008	-4.10	0.0008
	225026_at	chromodomain helicase DNA binding protein 6	CHD6	84181	1.72	0.0039	-2.28	0.0064
	225357_s_at	INO80 complex homolog 1 (S. cerevisiae)	INOC1	54617	1.95	0.0026	-2.48	0.0045
	243003_at	Myeloid/lymphoid leukemia; translocated to, 10	MLLT10	8028	1.61	0.0032	-2.01	0.0100
	1563321_s_at	Myeloid/lymphoid leukemia; translocated to, 10	MLLT10	8028	1.81	0.0071	-2.39	0.0046
	201703_s_at	protein phosphatase 1, regulatory subunit 10	PPP1R10	5514	1.81	0.0027	-3.88	0.0013
	209486_at	disrupter of silencing 10	SAS10	57050	2.02	0.0015	-5.61	0.0012
	225655_at	ubiquitin-like, with PHD & RING finger domains, 1	UHRF1	29128	1.56	0.0040	-1.63	0.0095
	1554441_a_at	wings apart-like homolog (Drosophila)	WAPAL	23063	1.67	0.0037	-3.00	0.0029
	212267_at	wings apart-like homolog (Drosophila)	WAPAL	23063	2.47	0.0017	-4.81	0.0033
RNA Binding and Processing	225694_at	Cdc2-related kinase, arginine/serine-rich	CRKRS	51755	1.51	0.0023	-2.96	0.0070
	218092_s_at	HIV-1 Rev binding protein	HRB	3267	1.54	0.0074	-1.64	0.0070
	223295_s_at	LUC7-like (S. cerevisiae)	LUC7L	55692	1.82	0.0020	-1.87	0.0032
	203378_at	PCF11, cleavage and polyadenylation factor subunit	PCF11	51585	2.36	0.0015	-3.89	0.0020
	238122_at	RNA binding motif protein 12B	RBM12B	389677	2.75	0.0010	-2.61	0.0013
	51228_at	RNA binding motif protein 12B	RBM12B	389677	1.81	0.0022	-2.63	0.0078
	201586_s_at	splicing factor proline/glutamine-rich	SFPQ	6421	1.51	0.0044	-1.77	0.0020
	217833_at	synaptotagmin binding, cytoplasmic RNA interacting	SYNCRIP	10492	1.52	0.0083	-1.54	0.0096
	203519_s_at	UPF2 regulator of nonsense transcripts	UPF2	26019	1.60	0.0059	-1.90	0.0080

^aAffymetrix designation
^bAbbreviated gene description
^cNCBI GeneID designation
^dFold change in response to 1.25uM PCI-2050
^eBenjamini-Hochberg corrected Student's t-test
^fFold change in response to 5ug/mL actinomycin D

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ISSN: 1476-4598

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