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Table 1 Upregulated genes in primary pancreatic tumors. Relative fold change in primary pancreatic tumors compared to normal pancreas (PT/NP) and in liver metastatic lesions compared to primary pancreatic tumors (LM/PT).

From: Gene expression profiles in primary pancreatic tumors and metastatic lesions of Ela-c-myc transgenic mice

Entrez Gene Fold change LM*/PT* Fold change PT/NP* Gene Symbol Gene description Ref.*
Mitochondrial ribosomal subunits
77721 1.0 4.2 Mrps5 Mitochondrial ribosomal protein S5  
69527 1.0 4.5 Mrps9 Mitochondrial ribosomal protein S9  
94063 1.0 4.1 Mrpl16 Mitochondrial ribosomal protein L16  
56284 0.9 5.0 Mrpl19 Mitochondrial ribosomal protein L19  
66407 0.8 4.1 Mrps15 Mitochondrial ribosomal protein S15  
64655 1.2 7.6 Mrps22 Mitochondrial ribosomal protein S22  
64658 1.0 4.1 Mrps25 Mitochondrial ribosomal protein S25  
Nucleolar and nucleosome assembly proteins
53605 0.9 13.5 Nap1l1 Nucleosome assembly protein 1-like 1 10, 11
110109 0.9 4.3 Nol1 Nucleolar protein 1  
52530 1.0 10.0 Nola2 Nucleolar protein family A, member 2  
100608 1.1 9.4 Noc4l Nucleolar complex associated 4 homolog  
55989 0.8 6.3 Nol5 Nucleolar protein 5  
67134 0.9 7.8 Nol5a Nucleolar protein 5A  
Small nuclear ribonucleoprotein complex
68981 1.1 8.7 Snrpa1 Small nuclear ribonucleoprotein polypeptide A'  
20638 0.9 8.3 Snrpb Small nuclear ribonucleoprotein B  
20641 1.1 7.1 Snrpd1 Small nuclear ribonucleoprotein D1  
67332 1.1 7.4 Snrpd3 Small nuclear ribonucleoprotein D3  
69878 1.1 6.9 Snrpf Small nuclear ribonucleoprotein polypeptide F  
666609 1.0 7.6 Snrpg small nuclear ribonucleoprotein polypeptide G  
Splicing factor
110809 1.1 5.5 Sfrs1 Splicing factor, arginine/serine-rich 1 (ASF/SF2)  
20382 1.1 5.1 Sfrs2 Splicing factor, arginine/serine-rich 2 (SC-35)  
20383 1.1 5.0 Sfrs3 Splicing factor, arginine/serine-rich 3 (SRp20)  
81898 1.2 5.2 Sf3b1 Splicing factor 3b, subunit 1 15
66125 1.2 8.0 Sf3b5 Splicing factor 3b, subunit 5 15
225027 1.2 4.1 Sfrs7 Splicing factor, arginine/serine-rich 7  
RNA binding and pre-mRNA processing factors
28000 1.1 4.7 Prpf19 PRP19/PSO4 pre-mRNA processing factor 19 homolog  
68988 1.1 5.0 Prpf31 PRP31 pre-mRNA processing factor 31 homolog (yeast)  
56194 1.1 5.8 Prpf40a PRP40 pre-mRNA processing factor 40 homolog A (yeast)  
56275 0.9 5.5 Rbm14 RNA binding motif protein 14  
67071 1.0 16.2 Rps6ka6 (Rsk4) Ribosomal protein S6 kinase polypeptide 6  
Spliceosome complex
81898 1.2 5.2 Sf3b1 Splicing factor 3b, subunit 1 15
66125 1.2 8.0 Sf3b5 Splicing factor 3b, subunit 5 15
20382 1.1 4.9 Sfrs2 Splicing factor, arginine/serine-rich 2 (SC-35)  
68981 1.1 8.7 Snrpa1 Small nuclear ribonucleoprotein polypeptide A'  
20638 0.9 8.3 Snrpb Small nuclear ribonucleoprotein B  
20641 1.1 7.1 Snrpd1 Small nuclear ribonucleoprotein D1  
69878 1.1 6.9 Snrpf Small nuclear ribonucleoprotein polypeptide F  
666609 1.0 7.6 Snrpg small nuclear ribonucleoprotein polypeptide G  
Cell proliferation and cell cycle regulation related genes
12428 1.0 16.6 Ccna2 Cyclin A2  
268697 1.2 11.2 Ccnb1 Cyclin B1  
12429 1.1 17.9 Ccnb1-rs1 Cyclin B1, related sequence 1  
12442 0.9 17.8 Ccnb2 Cyclin B2 15, 25
12448 1.3 4.9 Ccne2 Cyclin E2  
12449 0.9 8.9 Ccnf Cyclin F  
17216 0.9 9.0 Mcm2 Minichromosome maintenance deficient 2 14
17215 0.9 8.6 Mcm3 Minichromosome maintenance deficient 3  
17217 1.2 8.6 Mcm4 Minichromosome maintenance deficient 4 10
17218 1.0 11.8 Mcm5 Minichromosome maintenance deficient 5  
17219 1.1 20.1 Mcm6 Minichromosome maintenance deficient 6  
17220 0.9 11.0 Mcm7 Minichromosome maintenance deficient 7 14
70024 1.1 6.3 Mcm10 Minichromosome maintenance deficient 10  
11799 1.0 11.1 Birc5 Baculoviral IAP repeat-containing 5  
12211 1.0 4.4 Birc6 Baculoviral IAP repeat-containing 6  
12189 1.0 5.5 Brca1 Breast cancer 1  
70099 0.9 17.3 Smc4l1 Structural maintenance of chromosomes 4  
19361 1.0 15.1 Rad51 RAD51 homolog (S. cerevisiae)  
Cell adhesion and migration
12774 1.1 6.7 Ccr5 Chemokine (C-C motif) receptor 5  
56492 1.4 6.6 Cldn18 Claudin 18 25
Cell communication and signal trasduction
75590 0.8 30.3 Dusp9 Dual specificity phosphatase 9  
67071 1.0 16.2 Rps6ka6 (Rsk4) Ribosomal protein S6 kinase polypeptide 6  
12774 1.1 6.7 Ccr5 Chemokine (C-C motif) receptor 5  
56275 0.9 5.5 Rbm14 RNA binding motif protein 14  
12309 0.7 109.4 S100g S100 calcium binding protein G 10, 25
Apoptosis regulation related
11799 1.0 11.1 Birc5 Baculoviral IAP repeat-containing 5 16
17218 1.0 11.8 Mcm5 Minichromosome maintenance deficient 5,  
17319 1.1 6.8 Mif Macrophage migration inhibitory factor  
Chromosome organization and biogenesis
14211 1.1 12.7 Smc2l1 Structural maintenance of chromosomes 2  
70099 0.9 17.3 Smc4l1 Structural maintenance of chromosomes 4  
226026 1.0 5.4 Smc5l1 Structural maintenance of chromosomes 5  
19361 1.0 15.1 Rad51 RAD51 homolog (S. cerevisiae) 12
12189 1.0 5.5 Brca1 Breast cancer 1  
53605 0.9 13.5 Nap1l1 Nucleosome assembly protein 1-like 1 10, 11
17216 0.9 9.0 Mcm2 Minichromosome maintenance deficient 2 mitotin  
17218 1.0 11.8 Mcm5 Minichromosome maintenance deficient 5  
Transcriptional regulator
22431 0.6 2.7 Wt1 Wilms' tumor suppressor gene 57
  1. NP = Normal pancreas; PT = Primary pancreatic tumor; LM = liver metastatic lesion; Ref.* = References identifying genes previously shown to have deregulated expression in pancreatic cancer