Table 1 Upregulated genes in primary pancreatic tumors. Relative fold change in primary pancreatic tumors compared to normal pancreas (PT/NP) and in liver metastatic lesions compared to primary pancreatic tumors (LM/PT).
Entrez Gene | Fold change LM*/PT* | Fold change PT/NP* | Gene Symbol | Gene description | Ref.* |
|---|---|---|---|---|---|
Mitochondrial ribosomal subunits | |||||
77721 | 1.0 | 4.2 | Mrps5 | Mitochondrial ribosomal protein S5 | Â |
69527 | 1.0 | 4.5 | Mrps9 | Mitochondrial ribosomal protein S9 | Â |
94063 | 1.0 | 4.1 | Mrpl16 | Mitochondrial ribosomal protein L16 | Â |
56284 | 0.9 | 5.0 | Mrpl19 | Mitochondrial ribosomal protein L19 | Â |
66407 | 0.8 | 4.1 | Mrps15 | Mitochondrial ribosomal protein S15 | Â |
64655 | 1.2 | 7.6 | Mrps22 | Mitochondrial ribosomal protein S22 | Â |
64658 | 1.0 | 4.1 | Mrps25 | Mitochondrial ribosomal protein S25 | Â |
Nucleolar and nucleosome assembly proteins | |||||
53605 | 0.9 | 13.5 | Nap1l1 | Nucleosome assembly protein 1-like 1 | 10, 11 |
110109 | 0.9 | 4.3 | Nol1 | Nucleolar protein 1 | Â |
52530 | 1.0 | 10.0 | Nola2 | Nucleolar protein family A, member 2 | Â |
100608 | 1.1 | 9.4 | Noc4l | Nucleolar complex associated 4 homolog | Â |
55989 | 0.8 | 6.3 | Nol5 | Nucleolar protein 5 | Â |
67134 | 0.9 | 7.8 | Nol5a | Nucleolar protein 5A | Â |
Small nuclear ribonucleoprotein complex | |||||
68981 | 1.1 | 8.7 | Snrpa1 | Small nuclear ribonucleoprotein polypeptide A' | Â |
20638 | 0.9 | 8.3 | Snrpb | Small nuclear ribonucleoprotein B | Â |
20641 | 1.1 | 7.1 | Snrpd1 | Small nuclear ribonucleoprotein D1 | Â |
67332 | 1.1 | 7.4 | Snrpd3 | Small nuclear ribonucleoprotein D3 | Â |
69878 | 1.1 | 6.9 | Snrpf | Small nuclear ribonucleoprotein polypeptide F | Â |
666609 | 1.0 | 7.6 | Snrpg | small nuclear ribonucleoprotein polypeptide G | Â |
Splicing factor | |||||
110809 | 1.1 | 5.5 | Sfrs1 | Splicing factor, arginine/serine-rich 1 (ASF/SF2) | Â |
20382 | 1.1 | 5.1 | Sfrs2 | Splicing factor, arginine/serine-rich 2 (SC-35) | Â |
20383 | 1.1 | 5.0 | Sfrs3 | Splicing factor, arginine/serine-rich 3 (SRp20) | Â |
81898 | 1.2 | 5.2 | Sf3b1 | Splicing factor 3b, subunit 1 | 15 |
66125 | 1.2 | 8.0 | Sf3b5 | Splicing factor 3b, subunit 5 | 15 |
225027 | 1.2 | 4.1 | Sfrs7 | Splicing factor, arginine/serine-rich 7 | Â |
RNA binding and pre-mRNA processing factors | |||||
28000 | 1.1 | 4.7 | Prpf19 | PRP19/PSO4 pre-mRNA processing factor 19 homolog | Â |
68988 | 1.1 | 5.0 | Prpf31 | PRP31 pre-mRNA processing factor 31 homolog (yeast) | Â |
56194 | 1.1 | 5.8 | Prpf40a | PRP40 pre-mRNA processing factor 40 homolog A (yeast) | Â |
56275 | 0.9 | 5.5 | Rbm14 | RNA binding motif protein 14 | Â |
67071 | 1.0 | 16.2 | Rps6ka6 (Rsk4) | Ribosomal protein S6 kinase polypeptide 6 | Â |
Spliceosome complex | |||||
81898 | 1.2 | 5.2 | Sf3b1 | Splicing factor 3b, subunit 1 | 15 |
66125 | 1.2 | 8.0 | Sf3b5 | Splicing factor 3b, subunit 5 | 15 |
20382 | 1.1 | 4.9 | Sfrs2 | Splicing factor, arginine/serine-rich 2 (SC-35) | Â |
68981 | 1.1 | 8.7 | Snrpa1 | Small nuclear ribonucleoprotein polypeptide A' | Â |
20638 | 0.9 | 8.3 | Snrpb | Small nuclear ribonucleoprotein B | Â |
20641 | 1.1 | 7.1 | Snrpd1 | Small nuclear ribonucleoprotein D1 | Â |
69878 | 1.1 | 6.9 | Snrpf | Small nuclear ribonucleoprotein polypeptide F | Â |
666609 | 1.0 | 7.6 | Snrpg | small nuclear ribonucleoprotein polypeptide G | Â |
Cell proliferation and cell cycle regulation related genes | |||||
12428 | 1.0 | 16.6 | Ccna2 | Cyclin A2 | Â |
268697 | 1.2 | 11.2 | Ccnb1 | Cyclin B1 | Â |
12429 | 1.1 | 17.9 | Ccnb1-rs1 | Cyclin B1, related sequence 1 | Â |
12442 | 0.9 | 17.8 | Ccnb2 | Cyclin B2 | 15, 25 |
12448 | 1.3 | 4.9 | Ccne2 | Cyclin E2 | Â |
12449 | 0.9 | 8.9 | Ccnf | Cyclin F | Â |
17216 | 0.9 | 9.0 | Mcm2 | Minichromosome maintenance deficient 2 | 14 |
17215 | 0.9 | 8.6 | Mcm3 | Minichromosome maintenance deficient 3 | Â |
17217 | 1.2 | 8.6 | Mcm4 | Minichromosome maintenance deficient 4 | 10 |
17218 | 1.0 | 11.8 | Mcm5 | Minichromosome maintenance deficient 5 | Â |
17219 | 1.1 | 20.1 | Mcm6 | Minichromosome maintenance deficient 6 | Â |
17220 | 0.9 | 11.0 | Mcm7 | Minichromosome maintenance deficient 7 | 14 |
70024 | 1.1 | 6.3 | Mcm10 | Minichromosome maintenance deficient 10 | Â |
11799 | 1.0 | 11.1 | Birc5 | Baculoviral IAP repeat-containing 5 | Â |
12211 | 1.0 | 4.4 | Birc6 | Baculoviral IAP repeat-containing 6 | Â |
12189 | 1.0 | 5.5 | Brca1 | Breast cancer 1 | Â |
70099 | 0.9 | 17.3 | Smc4l1 | Structural maintenance of chromosomes 4 | Â |
19361 | 1.0 | 15.1 | Rad51 | RAD51 homolog (S. cerevisiae) | Â |
Cell adhesion and migration | |||||
12774 | 1.1 | 6.7 | Ccr5 | Chemokine (C-C motif) receptor 5 | Â |
56492 | 1.4 | 6.6 | Cldn18 | Claudin 18 | 25 |
Cell communication and signal trasduction | |||||
75590 | 0.8 | 30.3 | Dusp9 | Dual specificity phosphatase 9 | Â |
67071 | 1.0 | 16.2 | Rps6ka6 (Rsk4) | Ribosomal protein S6 kinase polypeptide 6 | Â |
12774 | 1.1 | 6.7 | Ccr5 | Chemokine (C-C motif) receptor 5 | Â |
56275 | 0.9 | 5.5 | Rbm14 | RNA binding motif protein 14 | Â |
12309 | 0.7 | 109.4 | S100g | S100 calcium binding protein G | 10, 25 |
Apoptosis regulation related | |||||
11799 | 1.0 | 11.1 | Birc5 | Baculoviral IAP repeat-containing 5 | 16 |
17218 | 1.0 | 11.8 | Mcm5 | Minichromosome maintenance deficient 5, | Â |
17319 | 1.1 | 6.8 | Mif | Macrophage migration inhibitory factor | Â |
Chromosome organization and biogenesis | |||||
14211 | 1.1 | 12.7 | Smc2l1 | Structural maintenance of chromosomes 2 | Â |
70099 | 0.9 | 17.3 | Smc4l1 | Structural maintenance of chromosomes 4 | Â |
226026 | 1.0 | 5.4 | Smc5l1 | Structural maintenance of chromosomes 5 | Â |
19361 | 1.0 | 15.1 | Rad51 | RAD51 homolog (S. cerevisiae) | 12 |
12189 | 1.0 | 5.5 | Brca1 | Breast cancer 1 | Â |
53605 | 0.9 | 13.5 | Nap1l1 | Nucleosome assembly protein 1-like 1 | 10, 11 |
17216 | 0.9 | 9.0 | Mcm2 | Minichromosome maintenance deficient 2 mitotin | Â |
17218 | 1.0 | 11.8 | Mcm5 | Minichromosome maintenance deficient 5 | Â |
Transcriptional regulator | |||||
22431 | 0.6 | 2.7 | Wt1 | Wilms' tumor suppressor gene | 57 |