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Table 1 Upregulated genes in primary pancreatic tumors. Relative fold change in primary pancreatic tumors compared to normal pancreas (PT/NP) and in liver metastatic lesions compared to primary pancreatic tumors (LM/PT).
| Entrez Gene | Fold change LM*/PT* | Fold change PT/NP* | Gene Symbol | Gene description | Ref.* |
|---|---|---|---|---|---|
| Mitochondrial ribosomal subunits | |||||
| 77721 | 1.0 | 4.2 | Mrps5 | Mitochondrial ribosomal protein S5 | |
| 69527 | 1.0 | 4.5 | Mrps9 | Mitochondrial ribosomal protein S9 | |
| 94063 | 1.0 | 4.1 | Mrpl16 | Mitochondrial ribosomal protein L16 | |
| 56284 | 0.9 | 5.0 | Mrpl19 | Mitochondrial ribosomal protein L19 | |
| 66407 | 0.8 | 4.1 | Mrps15 | Mitochondrial ribosomal protein S15 | |
| 64655 | 1.2 | 7.6 | Mrps22 | Mitochondrial ribosomal protein S22 | |
| 64658 | 1.0 | 4.1 | Mrps25 | Mitochondrial ribosomal protein S25 | |
| Nucleolar and nucleosome assembly proteins | |||||
| 53605 | 0.9 | 13.5 | Nap1l1 | Nucleosome assembly protein 1-like 1 | 10, 11 |
| 110109 | 0.9 | 4.3 | Nol1 | Nucleolar protein 1 | |
| 52530 | 1.0 | 10.0 | Nola2 | Nucleolar protein family A, member 2 | |
| 100608 | 1.1 | 9.4 | Noc4l | Nucleolar complex associated 4 homolog | |
| 55989 | 0.8 | 6.3 | Nol5 | Nucleolar protein 5 | |
| 67134 | 0.9 | 7.8 | Nol5a | Nucleolar protein 5A | |
| Small nuclear ribonucleoprotein complex | |||||
| 68981 | 1.1 | 8.7 | Snrpa1 | Small nuclear ribonucleoprotein polypeptide A' | |
| 20638 | 0.9 | 8.3 | Snrpb | Small nuclear ribonucleoprotein B | |
| 20641 | 1.1 | 7.1 | Snrpd1 | Small nuclear ribonucleoprotein D1 | |
| 67332 | 1.1 | 7.4 | Snrpd3 | Small nuclear ribonucleoprotein D3 | |
| 69878 | 1.1 | 6.9 | Snrpf | Small nuclear ribonucleoprotein polypeptide F | |
| 666609 | 1.0 | 7.6 | Snrpg | small nuclear ribonucleoprotein polypeptide G | |
| Splicing factor | |||||
| 110809 | 1.1 | 5.5 | Sfrs1 | Splicing factor, arginine/serine-rich 1 (ASF/SF2) | |
| 20382 | 1.1 | 5.1 | Sfrs2 | Splicing factor, arginine/serine-rich 2 (SC-35) | |
| 20383 | 1.1 | 5.0 | Sfrs3 | Splicing factor, arginine/serine-rich 3 (SRp20) | |
| 81898 | 1.2 | 5.2 | Sf3b1 | Splicing factor 3b, subunit 1 | 15 |
| 66125 | 1.2 | 8.0 | Sf3b5 | Splicing factor 3b, subunit 5 | 15 |
| 225027 | 1.2 | 4.1 | Sfrs7 | Splicing factor, arginine/serine-rich 7 | |
| RNA binding and pre-mRNA processing factors | |||||
| 28000 | 1.1 | 4.7 | Prpf19 | PRP19/PSO4 pre-mRNA processing factor 19 homolog | |
| 68988 | 1.1 | 5.0 | Prpf31 | PRP31 pre-mRNA processing factor 31 homolog (yeast) | |
| 56194 | 1.1 | 5.8 | Prpf40a | PRP40 pre-mRNA processing factor 40 homolog A (yeast) | |
| 56275 | 0.9 | 5.5 | Rbm14 | RNA binding motif protein 14 | |
| 67071 | 1.0 | 16.2 | Rps6ka6 (Rsk4) | Ribosomal protein S6 kinase polypeptide 6 | |
| Spliceosome complex | |||||
| 81898 | 1.2 | 5.2 | Sf3b1 | Splicing factor 3b, subunit 1 | 15 |
| 66125 | 1.2 | 8.0 | Sf3b5 | Splicing factor 3b, subunit 5 | 15 |
| 20382 | 1.1 | 4.9 | Sfrs2 | Splicing factor, arginine/serine-rich 2 (SC-35) | |
| 68981 | 1.1 | 8.7 | Snrpa1 | Small nuclear ribonucleoprotein polypeptide A' | |
| 20638 | 0.9 | 8.3 | Snrpb | Small nuclear ribonucleoprotein B | |
| 20641 | 1.1 | 7.1 | Snrpd1 | Small nuclear ribonucleoprotein D1 | |
| 69878 | 1.1 | 6.9 | Snrpf | Small nuclear ribonucleoprotein polypeptide F | |
| 666609 | 1.0 | 7.6 | Snrpg | small nuclear ribonucleoprotein polypeptide G | |
| Cell proliferation and cell cycle regulation related genes | |||||
| 12428 | 1.0 | 16.6 | Ccna2 | Cyclin A2 | |
| 268697 | 1.2 | 11.2 | Ccnb1 | Cyclin B1 | |
| 12429 | 1.1 | 17.9 | Ccnb1-rs1 | Cyclin B1, related sequence 1 | |
| 12442 | 0.9 | 17.8 | Ccnb2 | Cyclin B2 | 15, 25 |
| 12448 | 1.3 | 4.9 | Ccne2 | Cyclin E2 | |
| 12449 | 0.9 | 8.9 | Ccnf | Cyclin F | |
| 17216 | 0.9 | 9.0 | Mcm2 | Minichromosome maintenance deficient 2 | 14 |
| 17215 | 0.9 | 8.6 | Mcm3 | Minichromosome maintenance deficient 3 | |
| 17217 | 1.2 | 8.6 | Mcm4 | Minichromosome maintenance deficient 4 | 10 |
| 17218 | 1.0 | 11.8 | Mcm5 | Minichromosome maintenance deficient 5 | |
| 17219 | 1.1 | 20.1 | Mcm6 | Minichromosome maintenance deficient 6 | |
| 17220 | 0.9 | 11.0 | Mcm7 | Minichromosome maintenance deficient 7 | 14 |
| 70024 | 1.1 | 6.3 | Mcm10 | Minichromosome maintenance deficient 10 | |
| 11799 | 1.0 | 11.1 | Birc5 | Baculoviral IAP repeat-containing 5 | |
| 12211 | 1.0 | 4.4 | Birc6 | Baculoviral IAP repeat-containing 6 | |
| 12189 | 1.0 | 5.5 | Brca1 | Breast cancer 1 | |
| 70099 | 0.9 | 17.3 | Smc4l1 | Structural maintenance of chromosomes 4 | |
| 19361 | 1.0 | 15.1 | Rad51 | RAD51 homolog (S. cerevisiae) | |
| Cell adhesion and migration | |||||
| 12774 | 1.1 | 6.7 | Ccr5 | Chemokine (C-C motif) receptor 5 | |
| 56492 | 1.4 | 6.6 | Cldn18 | Claudin 18 | 25 |
| Cell communication and signal trasduction | |||||
| 75590 | 0.8 | 30.3 | Dusp9 | Dual specificity phosphatase 9 | |
| 67071 | 1.0 | 16.2 | Rps6ka6 (Rsk4) | Ribosomal protein S6 kinase polypeptide 6 | |
| 12774 | 1.1 | 6.7 | Ccr5 | Chemokine (C-C motif) receptor 5 | |
| 56275 | 0.9 | 5.5 | Rbm14 | RNA binding motif protein 14 | |
| 12309 | 0.7 | 109.4 | S100g | S100 calcium binding protein G | 10, 25 |
| Apoptosis regulation related | |||||
| 11799 | 1.0 | 11.1 | Birc5 | Baculoviral IAP repeat-containing 5 | 16 |
| 17218 | 1.0 | 11.8 | Mcm5 | Minichromosome maintenance deficient 5, | |
| 17319 | 1.1 | 6.8 | Mif | Macrophage migration inhibitory factor | |
| Chromosome organization and biogenesis | |||||
| 14211 | 1.1 | 12.7 | Smc2l1 | Structural maintenance of chromosomes 2 | |
| 70099 | 0.9 | 17.3 | Smc4l1 | Structural maintenance of chromosomes 4 | |
| 226026 | 1.0 | 5.4 | Smc5l1 | Structural maintenance of chromosomes 5 | |
| 19361 | 1.0 | 15.1 | Rad51 | RAD51 homolog (S. cerevisiae) | 12 |
| 12189 | 1.0 | 5.5 | Brca1 | Breast cancer 1 | |
| 53605 | 0.9 | 13.5 | Nap1l1 | Nucleosome assembly protein 1-like 1 | 10, 11 |
| 17216 | 0.9 | 9.0 | Mcm2 | Minichromosome maintenance deficient 2 mitotin | |
| 17218 | 1.0 | 11.8 | Mcm5 | Minichromosome maintenance deficient 5 | |
| Transcriptional regulator | |||||
| 22431 | 0.6 | 2.7 | Wt1 | Wilms' tumor suppressor gene | 57 |
