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Table 2 Downregulated genes in primary pancreatic tumors. Relative fold change in primary pancreatic tumors compared to normal pancreas (PT/NP) and in liver metastatic lesions compared to primary pancreatic tumors (LM/PT)

From: Gene expression profiles in primary pancreatic tumors and metastatic lesions of Ela-c-myc transgenic mice

Entrez Gene# Fold change LM/PT Fold change PT/NP Gene Symbol Gene description Ref.*
Cell adhesion, motility and migration
12340 0.84 -11.6 Capza1 Capping protein (actin filament) muscle Z-line, alpha 1 16
12829 0.98 -10.8 Col4a4 Procollagen, type IV, alpha 4  
13643 1.02 -7.6 Efnb3 Ephrin B3  
215384 1.03 -8 Fcgbp Fc fragment of IgG binding protein  
16855 1.00 -6.4 Lgals4 Lectin, galactose binding, soluble 4  
17831 1.02 -40 Muc2 Mucin 2  
219228 1.51 -18.8 Pcdh17 Protocadherin 17  
68799 1.20 -7.2 Rgmb RGM domain family, member B  
16855 1.00 -6.4 Lgals4 Lectin, galactose binding, soluble 4  
Cell communication and signal trasduction
12154 1.09 -4 Bmp10 Bone morphogenetic protein 10  
13643 1.02 -7.6 Efnb3 Ephrin B3  
14463 1.01 -8 Gata4 GATA binding protein 4  
15874 0.96 -40 Iapp Islet amyloid polypeptide  
16333 0.85 -23.2 Ins1 Insulin I  
14526 0.91 -21.6 Gcg Glucagon  
70497 0.86 -8 Arhgap17 Rho GTPase activating protein 17  
232201 0.83 -7.6 Arhgap25 Rho GTPase activating protein 25  
110052 1.00 -8.4 Dek DEK oncogene (DNA binding) 16
14915 0.98 -13.6 Guca2a Guanylate cyclase activator 2a (guanylin)  
212307 0.81 -7.2 Mapre2 Microtubule-associated protein, RP/EB family, member 2  
20844 1.15 -13.6 Stam Signal transducing adaptor molecule  
66042 0.85 -14.8 Sostdc1 Sclerostin domain containing 1  
68799 1.20 -7.2 Rgmb RGM domain family, member B  
80718 0.91 -6.4 Rab27b RAB27b, member RAS oncogene family  
18386 0.93 -6 Oprd1 Opioid receptor, delta 1  
67709 0.88 -13.6 Reg4 Regenerating islet-derived family, member 4  
Cell cycle and cell proliferation
76499 1.02 -8.8 Clasp2 CLIP associating protein 2  
16333 0.85 -23.2 Ins1 Insulin I  
16334 0.98 -40 Ins2 Insulin II  
212307 0.81 -7.2 Mapre2 Microtubule-associated protein, RP/EB family, member 2  
22268 0.90 -6 Upk1b Uroplakin 1B  
14526 0.91 -21.6 Gcg Glucagon  
212307 0.81 -7.2 Mapre2 Microtubule-associated protein, RP/EB family, member 2  
57263 1.11 -28 Retnlb Resistin like beta  
12154 1.09 -4 Bmp10 Bone morphogenetic protein 10  
17831 1.02 -40 Muc2 Mucin 2 19
17063 0.91 -60 Muc13 Mucin 13, epithelial transmembrane  
Transporter and binding activity
11773 1.09 -14.8 Ap2m1 Adaptor protein complex AP-2, mu1  
80718 0.91 -6.4 Rab27b RAB27b, member RAS oncogene family  
56185 1.00 -19.2 Hao3 Hydroxyacid oxidase (glycolate oxidase) 3  
110052 1.00 -8.4 Dek DEK oncogene (DNA binding) 16
12829 0.98 -10.8 Col4a4 Procollagen, type IV, alpha 4  
16467 1.13 -11.6 Atcay Ataxia, cerebellar, Cayman type homolog (human)  
13487 0.95 -20 Slc26a3 Solute carrier family 26, member 3  
216156 0.92 -4 Wdr18 WD repeat domain 18  
69008 1.23 -6.4 Cab39l Calcium binding protein 39-like  
12351 0.84 -4 Car4 Carbonic anhydrase 4  
72832 0.93 -14.8 Crtac1 Cartilage acidic protein 1  
75600 1.20 -8 Calml4 Calmodulin-like 4  
Apoptosis
15874 0.96 -40 Iapp Islet amyloid polypeptide  
17831 1.02 -40 Muc2 Mucin 2 19
71361 1.15 -8 Amid Apoptosis-inducing factor, mitochondrion-associated 2  
16334 0.98 -40 Ins2 Insulin II  
17063 0.91 -60 Muc13 Mucin 13, epithelial transmembrane  
Transcription activity
109275 0.94 -4 Actr5 ARP5 actin-related protein 5 homolog (yeast)  
71458 0.89 -6 Bcor Bcl6 interacting corepressor  
14463 1.01   Gata4 GATA binding protein 4  
Epigenetic and chromatin modification
213742 1.00 -8.8 Xist Inactive X specific transcripts  
75796 0.86 -4 Cdyl2 Chromodomain protein, Y chromosome-like 2  
Inflammatory and immune response
21786 0.90 -10.8 Tff3 Trefoil factor 3, intestinal  
15101 0.90 -7.6 H60 Histocompatibility 60  
94071 1.00 -4 Clec2h C-type lectin domain family 2, member h  
Cell differentiation
12154 1.09 -4 Bmp10 Bone morphogenetic protein 10  
14463 1.01 -8 Gata4 GATA binding protein 4  
72324 0.86 -4 Plxdc1 Plexin domain containing 1  
20755 1.31 -16 Sprr2a Small proline-rich protein 2A  
22268 0.90 -6 Upk1b Uroplakin 1B  
75770 0.85 -8.4 Brsk2 BR serine/threonine kinase 2  
Maintenance of cell polarity and shape
76499 1.02 -8.8 Clasp2 CLIP associating protein 2  
20755 1.31 -16 Sprr2a Small proline-rich protein 2A  
  1. Ref.* = References identifying genes previously shown to have deregulated expression in pancreatic cancer