Table 2 Downregulated genes in primary pancreatic tumors. Relative fold change in primary pancreatic tumors compared to normal pancreas (PT/NP) and in liver metastatic lesions compared to primary pancreatic tumors (LM/PT)
Entrez Gene# | Fold change LM/PT | Fold change PT/NP | Gene Symbol | Gene description | Ref.* |
|---|---|---|---|---|---|
Cell adhesion, motility and migration | |||||
12340 | 0.84 | -11.6 | Capza1 | Capping protein (actin filament) muscle Z-line, alpha 1 | 16 |
12829 | 0.98 | -10.8 | Col4a4 | Procollagen, type IV, alpha 4 | Â |
13643 | 1.02 | -7.6 | Efnb3 | Ephrin B3 | Â |
215384 | 1.03 | -8 | Fcgbp | Fc fragment of IgG binding protein | Â |
16855 | 1.00 | -6.4 | Lgals4 | Lectin, galactose binding, soluble 4 | Â |
17831 | 1.02 | -40 | Muc2 | Mucin 2 | Â |
219228 | 1.51 | -18.8 | Pcdh17 | Protocadherin 17 | Â |
68799 | 1.20 | -7.2 | Rgmb | RGM domain family, member B | Â |
16855 | 1.00 | -6.4 | Lgals4 | Lectin, galactose binding, soluble 4 | Â |
Cell communication and signal trasduction | |||||
12154 | 1.09 | -4 | Bmp10 | Bone morphogenetic protein 10 | Â |
13643 | 1.02 | -7.6 | Efnb3 | Ephrin B3 | Â |
14463 | 1.01 | -8 | Gata4 | GATA binding protein 4 | Â |
15874 | 0.96 | -40 | Iapp | Islet amyloid polypeptide | Â |
16333 | 0.85 | -23.2 | Ins1 | Insulin I | Â |
14526 | 0.91 | -21.6 | Gcg | Glucagon | Â |
70497 | 0.86 | -8 | Arhgap17 | Rho GTPase activating protein 17 | Â |
232201 | 0.83 | -7.6 | Arhgap25 | Rho GTPase activating protein 25 | Â |
110052 | 1.00 | -8.4 | Dek | DEK oncogene (DNA binding) | 16 |
14915 | 0.98 | -13.6 | Guca2a | Guanylate cyclase activator 2a (guanylin) | Â |
212307 | 0.81 | -7.2 | Mapre2 | Microtubule-associated protein, RP/EB family, member 2 | Â |
20844 | 1.15 | -13.6 | Stam | Signal transducing adaptor molecule | Â |
66042 | 0.85 | -14.8 | Sostdc1 | Sclerostin domain containing 1 | Â |
68799 | 1.20 | -7.2 | Rgmb | RGM domain family, member B | Â |
80718 | 0.91 | -6.4 | Rab27b | RAB27b, member RAS oncogene family | Â |
18386 | 0.93 | -6 | Oprd1 | Opioid receptor, delta 1 | Â |
67709 | 0.88 | -13.6 | Reg4 | Regenerating islet-derived family, member 4 | Â |
Cell cycle and cell proliferation | |||||
76499 | 1.02 | -8.8 | Clasp2 | CLIP associating protein 2 | Â |
16333 | 0.85 | -23.2 | Ins1 | Insulin I | Â |
16334 | 0.98 | -40 | Ins2 | Insulin II | Â |
212307 | 0.81 | -7.2 | Mapre2 | Microtubule-associated protein, RP/EB family, member 2 | Â |
22268 | 0.90 | -6 | Upk1b | Uroplakin 1B | Â |
14526 | 0.91 | -21.6 | Gcg | Glucagon | Â |
212307 | 0.81 | -7.2 | Mapre2 | Microtubule-associated protein, RP/EB family, member 2 | Â |
57263 | 1.11 | -28 | Retnlb | Resistin like beta | Â |
12154 | 1.09 | -4 | Bmp10 | Bone morphogenetic protein 10 | Â |
17831 | 1.02 | -40 | Muc2 | Mucin 2 | 19 |
17063 | 0.91 | -60 | Muc13 | Mucin 13, epithelial transmembrane | Â |
Transporter and binding activity | |||||
11773 | 1.09 | -14.8 | Ap2m1 | Adaptor protein complex AP-2, mu1 | Â |
80718 | 0.91 | -6.4 | Rab27b | RAB27b, member RAS oncogene family | Â |
56185 | 1.00 | -19.2 | Hao3 | Hydroxyacid oxidase (glycolate oxidase) 3 | Â |
110052 | 1.00 | -8.4 | Dek | DEK oncogene (DNA binding) | 16 |
12829 | 0.98 | -10.8 | Col4a4 | Procollagen, type IV, alpha 4 | Â |
16467 | 1.13 | -11.6 | Atcay | Ataxia, cerebellar, Cayman type homolog (human) | Â |
13487 | 0.95 | -20 | Slc26a3 | Solute carrier family 26, member 3 | Â |
216156 | 0.92 | -4 | Wdr18 | WD repeat domain 18 | Â |
69008 | 1.23 | -6.4 | Cab39l | Calcium binding protein 39-like | Â |
12351 | 0.84 | -4 | Car4 | Carbonic anhydrase 4 | Â |
72832 | 0.93 | -14.8 | Crtac1 | Cartilage acidic protein 1 | Â |
75600 | 1.20 | -8 | Calml4 | Calmodulin-like 4 | Â |
Apoptosis | |||||
15874 | 0.96 | -40 | Iapp | Islet amyloid polypeptide | Â |
17831 | 1.02 | -40 | Muc2 | Mucin 2 | 19 |
71361 | 1.15 | -8 | Amid | Apoptosis-inducing factor, mitochondrion-associated 2 | Â |
16334 | 0.98 | -40 | Ins2 | Insulin II | Â |
17063 | 0.91 | -60 | Muc13 | Mucin 13, epithelial transmembrane | Â |
Transcription activity | |||||
109275 | 0.94 | -4 | Actr5 | ARP5 actin-related protein 5 homolog (yeast) | Â |
71458 | 0.89 | -6 | Bcor | Bcl6 interacting corepressor | Â |
14463 | 1.01 | Â | Gata4 | GATA binding protein 4 | Â |
Epigenetic and chromatin modification | |||||
213742 | 1.00 | -8.8 | Xist | Inactive X specific transcripts | Â |
75796 | 0.86 | -4 | Cdyl2 | Chromodomain protein, Y chromosome-like 2 | Â |
Inflammatory and immune response | |||||
21786 | 0.90 | -10.8 | Tff3 | Trefoil factor 3, intestinal | Â |
15101 | 0.90 | -7.6 | H60 | Histocompatibility 60 | Â |
94071 | 1.00 | -4 | Clec2h | C-type lectin domain family 2, member h | Â |
Cell differentiation | |||||
12154 | 1.09 | -4 | Bmp10 | Bone morphogenetic protein 10 | Â |
14463 | 1.01 | -8 | Gata4 | GATA binding protein 4 | Â |
72324 | 0.86 | -4 | Plxdc1 | Plexin domain containing 1 | Â |
20755 | 1.31 | -16 | Sprr2a | Small proline-rich protein 2A | Â |
22268 | 0.90 | -6 | Upk1b | Uroplakin 1B | Â |
75770 | 0.85 | -8.4 | Brsk2 | BR serine/threonine kinase 2 | Â |
Maintenance of cell polarity and shape | |||||
76499 | 1.02 | -8.8 | Clasp2 | CLIP associating protein 2 | Â |
20755 | 1.31 | -16 | Sprr2a | Small proline-rich protein 2A | Â |