Table 3 Upregulated genes in liver metastatic lesions. Relative fold change in liver metastatic lesions compared to primary pancreatic tumors (LM/PT) and in primary pancreatic tumors compared to normal pancreas (PT/NP)
Entrez Gene # | Fold change LM/PT | Fold change PT/NP | Gene Symbol | Gene description | Ref.* |
|---|---|---|---|---|---|
Transporter activity | |||||
27413 | 5.1 | 0.6 | Abcb11 | ATP-binding cassette, sub-family B (MDR/TAP), member 11 | Â |
12870 | 11.8 | 0.9 | Cp | Ceruloplasmin | Â |
107141 | 4.2 | 1.1 | Cyp2c37 | Cytochrome P450, family 2. subfamily c, polypeptide 37 | Â |
76279 | 9.1 | 0.6 | Cyp2d26 | Cytochrome P450, family 2. subfamily d, polypeptide 26 | Â |
13107 | 7.8 | 0.3 | Cyp2f2 | Cytochrome P450, family 2, subfamily f, polypeptide 2 | Â |
14263 | 11.3 | 0.4 | Fmo5 | Flavin containing monooxygenase 5 | Â |
268756 | 9.0 | 0.5 | Gulo | Gulonolactone (L-) oxidase | Â |
20493 | 8.3 | 0.3 | Slc10a1 | Solute carrier family 10 member 1 | Â |
69354 | 8.3 | 1.0 | Slc38a4 | Solute carrier family 38, member 4 | Â |
28253 | 4.9 | 0.9 | Slco1b2 | Solute carrier organic anion transporter family, member 1b2 | Â |
Cellular metabolism | |||||
67758 | 10.6 | 0.3 | Aadac | Arylacetamide deacetylase (esterase) | Â |
208665 | 11.4 | 0.3 | Akr1d1 | Aldo-keto reductase family 1, member D1 | Â |
11806 | 43.3 | 0.8 | Apoa1 | Apolipoprotein A-I | Â |
238055 | 12.2 | 0.6 | Apob | Apolipoprotein B | Â |
12116 | 33.0 | 0.6 | Bhmt | Betaine-homocysteine methyltransferase | Â |
14121 | 9.3 | 0.7 | Fbp1 | Fructose bisphosphatase 1 | Â |
227231 | 33.6 | 0.3 | Cps1 | Carbamoyl-phosphate synthetase 1 | Â |
231396 | 14.8 | 1.0 | Ugt2b36 | UDP glucuronosyltransferase 2 family, polypeptide B36 | Â |
15233 | 6.9 | 0.4 | Hgd | Homogentisate 1, 2-dioxygenase | Â |
15483 | 4.2 | 0.2 | Hsd11b1 | Hydroxysteroid 11-beta dehydrogenase 1 | Â |
13850 | 7.8 | 0.4 | Ephx2 | Epoxide hydrolase 2, cytoplasmic | Â |
13077 | 7.0 | 0.8 | Cyp1a2 | Cytochrome P450, family 1, subfamily a, polypeptide 2 | Â |
54150 | 18.2 | 0.5 | Rdh7 | Retinol dehydrogenase 7 | Â |
72094 | 7.4 | 1.0 | Ugt2a3 | UDP glucuronosyltransferase 2 family, polypeptide A3 | Â |
103149 | 6.3 | 0.6 | Upb1 | Ureidopropionase, beta | Â |
16922 | 5.4 | 0.4 | Phyh | Phytanoyl-CoA hydroxylase | Â |
Calcium binding activity | |||||
19733 | 11.6 | 0.5 | Rgn | Regucalcin | Â |
14067 | 6.9 | 0.5 | F5 | Coagulation factor V | Â |
16426 | 48.0 | 1.0 | Itih3 | Inter-alpha trypsin inhibitor, heavy chain 3 | Â |
Cell organization and biogenesis | |||||
11625 | 40.5 | 0.9 | Ahsg | Alpha-2-HS-glycoprotein | Â |
19699 | 5.5 | 0.5 | Reln | Reelin | Â |
16008 | 6.0 | 1.0 | Igfbp2 | Insulin-like growth factor binding protein 2 | Â |
14080 | 74.7 | 1.0 | Fabp1 | Fatty acid binding protein 1, liver | Â |
Protease Inhibitor activity | |||||
20700 | 24.9 | 4.1 | Serpina1a | Serine (or cysteine) peptidase inhibitor, clade A, member 1a | 25, 51 |
20702 | 100.1 | 0.4 | Serpina1c | Serine (or cysteine) peptidase inhibitor, clade A, member 1c | Â |
59083 | 22.8 | 0.3 | Fetub | Fetuin beta | Â |
Inflammatory and Immune response | |||||
12628 | 4.4 | 1.1 | Cfh | Complement component factor h | Â |
17175 | 4.5 | 1.0 | Masp2 | Mannan-binding lectin serine peptidase 2 | Â |
11625 | 40.5 | 0.9 | Ahsg | Alpha-2-HS-glycoprotein | Â |
15439 | 14.4 | 7.6 | Hp | Haptoglobin | Â |
18405 | 15.8 | 1.4 | Orm1 | Orosomucoid 1 | Â |
12583 | 8.4 | 0.8 | Cdo1 | Cysteine dioxygenase 1, cytosolic | Â |
13850 | 7.8 | 0.4 | Ephx2 | Epoxide hydrolase 2, cytoplasmic | Â |
11699 | 90.2 | 0.2 | Ambp | Alpha 1 microglobulin/bikunin | 28 |
Cell Adhesion | |||||
12558 | 4.7 | 1.0 | Cdh2 | Cadherin 2 | Â |
14067 | 6.9 | 0.5 | F5 | Coagulation factor V | Â |
16008 | 6.0 | 1.0 | Igfbp2 | Insulin-like growth factor binding protein 2 | Â |
19699 | 5.5 | 0.5 | Reln | Reelin | Â |
17175 | 4.5 | 1.0 | Masp2 | Mannan-binding lectin serine peptidase 2 | Â |
14080 | 74.7 | 1.0 | Fabp1 | Fatty acid binding protein 1, liver | Â |
Cell growth and cell cycle | |||||
14080 | 74.7 | 1.0 | Fabp1 | Fatty acid binding protein 1, liver | Â |
16008 | 6.0 | 1.0 | Igfbp2 | Insulin-like growth factor binding protein 2 | Â |
11625 | 40.5 | 0.9 | Ahsg | Alpha-2-HS-glycoprotein | Â |
Cell motility and migration | |||||
12558 | 4.7 | 1.0 | Cdh2 | Cadherin 2 | Â |
19699 | 5.5 | 0.5 | Reln | Reelin | Â |
16841 | 4.8 | 0.6 | Lect2 | Leukocyte cell-derived chemotaxin 2 | Â |
20315 | 4.5 | 0.1 | Cxcl12 | Chemokine (C-X-C motif) ligand 12 | Â |
12738 | 2.8 | 0.3 | Cldn2 | Claudin 2 | Â |
Cell communication and Signal Transduction | |||||
208665 | 11.4 | 0.3 | Akr1d1 | Aldo-keto reductase family 1, member D1 | Â |
22139 | 38.8 | 0.1 | Ttr | Transthyretin | Â |
16008 | 6.0 | 1.0 | Igfbp2 | Insulin-like growth factor binding protein 2 | Â |
20526 | 13.1 | 0.3 | Slc2a2 | Solute carrier family 2, member 2 | Â |
238055 | 12.2 | 0.6 | Apob | Apolipoprotein B | Â |
50765 | 4.4 | 0.7 | Trfr2 | Transferrin receptor 2 | Â |
107146 | 4.7 | 0.7 | Glyat | Glycine-N-acyltransferase | Â |
51811 | 5.7 | 0.7 | Clec4f | C-type lectin domain family 4, member f | Â |
14080 | 74.7 | 1.0 | Fabp1 | Fatty acid binding protein 1, liver | Â |
56720 | 4.0 | 0.8 | Tdo2 | Tryptophan 2,3-dioxygenase | Â |
11625 | 40.5 | 0.9 | Ahsg | Alpha-2-HS-glycoprotein | Â |
353283 | 4.1 | 42.0 | Eras | ES cell-expressed Ras | Â |
19699 | 5.5 | 0.5 | Reln | Reelin | Â |
16006 | 28.1 | 0.7 | Igfbp1 | Insulin-like growth factor binding protein 1 | 28,30,31 |