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Table 3 Upregulated genes in liver metastatic lesions. Relative fold change in liver metastatic lesions compared to primary pancreatic tumors (LM/PT) and in primary pancreatic tumors compared to normal pancreas (PT/NP)

From: Gene expression profiles in primary pancreatic tumors and metastatic lesions of Ela-c-myc transgenic mice

Entrez Gene # Fold change LM/PT Fold change PT/NP Gene Symbol Gene description Ref.*
Transporter activity
27413 5.1 0.6 Abcb11 ATP-binding cassette, sub-family B (MDR/TAP), member 11  
12870 11.8 0.9 Cp Ceruloplasmin  
107141 4.2 1.1 Cyp2c37 Cytochrome P450, family 2. subfamily c, polypeptide 37  
76279 9.1 0.6 Cyp2d26 Cytochrome P450, family 2. subfamily d, polypeptide 26  
13107 7.8 0.3 Cyp2f2 Cytochrome P450, family 2, subfamily f, polypeptide 2  
14263 11.3 0.4 Fmo5 Flavin containing monooxygenase 5  
268756 9.0 0.5 Gulo Gulonolactone (L-) oxidase  
20493 8.3 0.3 Slc10a1 Solute carrier family 10 member 1  
69354 8.3 1.0 Slc38a4 Solute carrier family 38, member 4  
28253 4.9 0.9 Slco1b2 Solute carrier organic anion transporter family, member 1b2  
Cellular metabolism
67758 10.6 0.3 Aadac Arylacetamide deacetylase (esterase)  
208665 11.4 0.3 Akr1d1 Aldo-keto reductase family 1, member D1  
11806 43.3 0.8 Apoa1 Apolipoprotein A-I  
238055 12.2 0.6 Apob Apolipoprotein B  
12116 33.0 0.6 Bhmt Betaine-homocysteine methyltransferase  
14121 9.3 0.7 Fbp1 Fructose bisphosphatase 1  
227231 33.6 0.3 Cps1 Carbamoyl-phosphate synthetase 1  
231396 14.8 1.0 Ugt2b36 UDP glucuronosyltransferase 2 family, polypeptide B36  
15233 6.9 0.4 Hgd Homogentisate 1, 2-dioxygenase  
15483 4.2 0.2 Hsd11b1 Hydroxysteroid 11-beta dehydrogenase 1  
13850 7.8 0.4 Ephx2 Epoxide hydrolase 2, cytoplasmic  
13077 7.0 0.8 Cyp1a2 Cytochrome P450, family 1, subfamily a, polypeptide 2  
54150 18.2 0.5 Rdh7 Retinol dehydrogenase 7  
72094 7.4 1.0 Ugt2a3 UDP glucuronosyltransferase 2 family, polypeptide A3  
103149 6.3 0.6 Upb1 Ureidopropionase, beta  
16922 5.4 0.4 Phyh Phytanoyl-CoA hydroxylase  
Calcium binding activity
19733 11.6 0.5 Rgn Regucalcin  
14067 6.9 0.5 F5 Coagulation factor V  
16426 48.0 1.0 Itih3 Inter-alpha trypsin inhibitor, heavy chain 3  
Cell organization and biogenesis
11625 40.5 0.9 Ahsg Alpha-2-HS-glycoprotein  
19699 5.5 0.5 Reln Reelin  
16008 6.0 1.0 Igfbp2 Insulin-like growth factor binding protein 2  
14080 74.7 1.0 Fabp1 Fatty acid binding protein 1, liver  
Protease Inhibitor activity
20700 24.9 4.1 Serpina1a Serine (or cysteine) peptidase inhibitor, clade A, member 1a 25, 51
20702 100.1 0.4 Serpina1c Serine (or cysteine) peptidase inhibitor, clade A, member 1c  
59083 22.8 0.3 Fetub Fetuin beta  
Inflammatory and Immune response
12628 4.4 1.1 Cfh Complement component factor h  
17175 4.5 1.0 Masp2 Mannan-binding lectin serine peptidase 2  
11625 40.5 0.9 Ahsg Alpha-2-HS-glycoprotein  
15439 14.4 7.6 Hp Haptoglobin  
18405 15.8 1.4 Orm1 Orosomucoid 1  
12583 8.4 0.8 Cdo1 Cysteine dioxygenase 1, cytosolic  
13850 7.8 0.4 Ephx2 Epoxide hydrolase 2, cytoplasmic  
11699 90.2 0.2 Ambp Alpha 1 microglobulin/bikunin 28
Cell Adhesion
12558 4.7 1.0 Cdh2 Cadherin 2  
14067 6.9 0.5 F5 Coagulation factor V  
16008 6.0 1.0 Igfbp2 Insulin-like growth factor binding protein 2  
19699 5.5 0.5 Reln Reelin  
17175 4.5 1.0 Masp2 Mannan-binding lectin serine peptidase 2  
14080 74.7 1.0 Fabp1 Fatty acid binding protein 1, liver  
Cell growth and cell cycle
14080 74.7 1.0 Fabp1 Fatty acid binding protein 1, liver  
16008 6.0 1.0 Igfbp2 Insulin-like growth factor binding protein 2  
11625 40.5 0.9 Ahsg Alpha-2-HS-glycoprotein  
Cell motility and migration
12558 4.7 1.0 Cdh2 Cadherin 2  
19699 5.5 0.5 Reln Reelin  
16841 4.8 0.6 Lect2 Leukocyte cell-derived chemotaxin 2  
20315 4.5 0.1 Cxcl12 Chemokine (C-X-C motif) ligand 12  
12738 2.8 0.3 Cldn2 Claudin 2  
Cell communication and Signal Transduction
208665 11.4 0.3 Akr1d1 Aldo-keto reductase family 1, member D1  
22139 38.8 0.1 Ttr Transthyretin  
16008 6.0 1.0 Igfbp2 Insulin-like growth factor binding protein 2  
20526 13.1 0.3 Slc2a2 Solute carrier family 2, member 2  
238055 12.2 0.6 Apob Apolipoprotein B  
50765 4.4 0.7 Trfr2 Transferrin receptor 2  
107146 4.7 0.7 Glyat Glycine-N-acyltransferase  
51811 5.7 0.7 Clec4f C-type lectin domain family 4, member f  
14080 74.7 1.0 Fabp1 Fatty acid binding protein 1, liver  
56720 4.0 0.8 Tdo2 Tryptophan 2,3-dioxygenase  
11625 40.5 0.9 Ahsg Alpha-2-HS-glycoprotein  
353283 4.1 42.0 Eras ES cell-expressed Ras  
19699 5.5 0.5 Reln Reelin  
16006 28.1 0.7 Igfbp1 Insulin-like growth factor binding protein 1 28,30,31
  1. Ref.* = References identifying genes previously shown to have deregulated expression in pancreatic cancer