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Table 4 Downregulated genes in liver metastatic lesions. Relative fold change in liver metastatic lesions compared to primary pancreatic tumors (LM/PT) and in primary pancreatic tumors compared to normal pancreas (PT/NP)

From: Gene expression profiles in primary pancreatic tumors and metastatic lesions of Ela-c-myc transgenic mice

Entrez Gene # LM/PT PT/NP Gene Symbol Gene description Ref.*
Cell communication and Signal transduction
22329 0.5 23.5 Vcam1 Vascular cell adhesion molecule 1  
58194 0.4 4.0 Sh3kbp1 SH3-domain kinase binding protein 1  
15186 0.1 15.0 Hdc Histidine decarboxylase  
11438 0.2 4.9 Chrna4 Cholinergic receptor, nicotinic, alpha polypeptide 4  
12524 0.6 4.6 Cd86 CD86 antigen  
93761 0.2 4.2 Smarca1 SWI/SNF related, regulator of chromatin, subfamily a, member 1  
Cell motility and migration
12767 0.7 4.7 Cxcr4 Chemokine (C-X-C motif) receptor 4 25
17381 2.8 7.6 Mmp12 Matrix metallopeptidase 12 16
11438 0.2 4.9 Chrna4 Cholinergic receptor, nicotinic, alpha polypeptide 4  
Cell Adhesion
12505 0.6 5.3 Cd44 CD44 antigen 11
22329 0.5 23.5 Vcam1 Vascular cell adhesion molecule 1  
Cell death and apoptosis
18616 0.2 11.2 Peg3 Paternally expressed 3  
11801 0.6 31.1 Cd5l CD5 antigen-like  
58194 0.4 4.0 Sh3kbp1 SH3-domain kinase binding protein 1  
Inflammatory and Immune response
20210 0.1 14.1 Saa3 Serum amyloid A 3  
58194 0.4 4.0 Sh3kbp1 SH3-domain kinase binding protein 1  
15186 0.1 15.0 Hdc Histidine decarboxylase  
  1. Ref.* = References identifying genes previously shown to have deregulated expression in pancreatic cancer