Figure 5
From: DNMT3b overexpression contributes to a hypermethylator phenotype in human breast cancer cell lines
DNMT activity levels in breast cancer cell lines correlate with DNMT3b expression. Association between DNMT total activity and DNMT3b protein levels for the 12 breast cancer cell lines and MCF12A cells. Hypermethylator cell lines (black triangles), low-frequency methylator cell lines (white triangles), and MCF12A cells (black circle) demonstrate a statistically significant relationship between DNMT total activity and DNMT3b protein levels.