Figure 2
From: Inducing apoptosis of human colon cancer cells by an IGF-I D domain analogue peptide
Following treatment by M1557 peptide for 40 hours, human colon cancer cell (HT-29) caspase3/7 (A), 8(B) and 9 (C) activities increased in a dose response manner. Caspase 3/7 activities in treated cancer cells increased 2–7 times compared to the untreated control cancer cells with significant effects at dose of 0.1 μM onward concentrations (P < 0.001). Caspase 8 activities in treated cancer cells also increased 2–5 times compared to the untreated control cancer cells, with significant effects at 0.1 μM onward concentrations (P < 0.001). Caspase 9 activities in treated cancer cells increased in a small scale (1.6 times), with significant effects at the higher concentrations (1 μM onward; P < 0.05) compared to caspase 3/7 and 8. Significance value: * P < 0.05; ** P < 0.001.