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Table 1 β-catenin mutations detected in HCCs. Indicated is the number of the codon affected and the resulting amino acid change as well as the phenotype observed by immunohistochemistry with regard to presence of β-catenin (cytoplasmic/nuclear) and GS-expression (GS).

From: Correlation between β-catenin mutations and expression of Wnt-signaling target genes in hepatocellular carcinoma

Patient number

Codon

Mutation

Aminoacid

β-Cat cytoplasmic

β-Cat nuclear

GS

20071/2,3,-00

33

TCT > TGT

S>C

+

+

+

30600/4-05

35

ATC>AGC

I>S

+

+

+

334/2-02

24138/E-01

36

CAT>CCT

H>P

+

+

+

14865/2-05

37

TCT>TGT

S>C

+

+

+

4836/3-05

37

TCT>TTT

S>F

+

+

+

21217-00

41

ACC>GCC

T>A

+

+

+

6700/2.3.-05

44

CCT>GCT

P>A

+

-

+

6700/2.3.-05

29923/B-03

45

TCT>CCT

S>P

+

-

+

28356/2-05

45

TCT>TTT

S>F

+

+

+