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Table 1 Gene expression profiling in HepG2 cells incubated with or without etoposide under normoxic or hypoxic conditions.

From: Hypoxia induces protection against etoposide-induced apoptosis: molecular profiling of changes in gene expression and transcription factor activity

  N Ne H He
BIRC3 1 2.99 1.53 2.31
CLK1 1 2.77 2.28 4.03
GADD45A 1 4.32 1.47 3.54
IGF2 1 2.67 1.59 1.57
IGFBP4 1 4.35 1.77 2.39
MCL1 1 3.44 3.92 5.27
ALDOA 1 1.00 1.43 1.59
BAG1 1 2.07 1.37 2.16
BIRC2 1 2.42 1.51 2.36
BIRC4 1 1.25 1.69 1.43
BNIP3 1 1.19 3.97 4.25
ING 1 1.48 1.83 1.97
JUN 1 1.66 2.33 3.28
MAP2K1 1 1.38 2.16 2.05
TANK 1 1.77 1.34 1.60
BAX 1 2.45 0.88 1.44
IGFBP2 1 1.83 1.21 1.30
MDM2 1 4.75 1.44 2.47
TNFRSF6 1 5.70 0.69 5.11
CASP1 1 2.84 1.00 1.71
GAPD 1 1.13 1.43 1.68
K-ALPHA-1 1 1.03 0.78 0.73
RPS9 1 1.30 1.19 1.48
CDK7 1 1.60 1.60 1.52
NFKB1 1 1.27 1.40 1.25
BCL2A1 1 2.01 0.85 1.27
CDKN1C 1 1.45 1.06 0.90
CDKN2B 1 1.64 0.98 0.81
MAPK12 1 1.96 1.10 1.06
RBL2 1 1.88 1.03 0.99
RBP1 1 2.05 1.01 1.16
RIPK1 1 1.58 0.87 1.00
TP53 1 1.82 0.68 0.85
TP73 1 1.62 1.06 0.94
YWHAZ 1 2.62 0.82 0.81
BIRC5 1 1.07 0.68 0.66
CDC25C 1 2.17 0.60 0.59
CDK2 1 1.14 0.73 0.76
MAPK9 1 1.15 0.76 0.67
TFDP1 1 1.23 0.69 0.63
GSR 1 0.72 0.92 0.60
GSA 1 0.51 0.67 0.69
BID 1 1.50 0.83 1.06
BIK 1 2.09 0.63 0.92
CDK9 1 1.48 0.75 0.72
CLU 1 1.54 0.81 1.09
BclX 1 1.85 1.11 0.81
CASP2 1 1.12 0.83 0.81
CDK4 1 0.72 0.98 0.74
CDK5R1 1 1.43 0.87 0.75
CDK6 1 1.18 1.30 0.52
CSE1L 1 1.05 1.01 0.71
GRB2 1 1.31 0.83 0.72
IGF1R 1 1.26 1.10 0.66
LTB 1 1.38 0.97 0.82
PLK 1 1.14 0.81 0.46
TNFSF7 1 1.50 1.00 0.74
TRAF3 1 1.40 0.89 0.76
BAK 1 1 3.42 0.75 2.13
CDKN1A 1 3.02 0.52 1.64
GPX1 1 2.88 0.69 1.43
CDC2 1 3.22 0.74 0.83
PCNA 1 2.23 0.62 1.68
AKT2 1 1.55 1.00 0.78
E2F5 1 1.20 1.90 0.61
  1. Cells were incubated under normoxic (N) or hypoxic (H) conditions with or without etoposide (e, 50 μM) for 16 hours before RNA extraction, reverse-transcription and cDNA hybridization, as described in Materials and Methods. Each value is the average of three ratio values calculated from three independent experiments. Mean ratios indicate a fold-increase or decrease in gene expression.
  2. Value higher than 1 + 1 SD, Value lower than 1 - 1 SD