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Table 1 Gene expression profiling in HepG2 cells incubated with or without etoposide under normoxic or hypoxic conditions.

From: Hypoxia induces protection against etoposide-induced apoptosis: molecular profiling of changes in gene expression and transcription factor activity

 

N

Ne

H

He

BIRC3

1

2.99

1.53

2.31

CLK1

1

2.77

2.28

4.03

GADD45A

1

4.32

1.47

3.54

IGF2

1

2.67

1.59

1.57

IGFBP4

1

4.35

1.77

2.39

MCL1

1

3.44

3.92

5.27

ALDOA

1

1.00

1.43

1.59

BAG1

1

2.07

1.37

2.16

BIRC2

1

2.42

1.51

2.36

BIRC4

1

1.25

1.69

1.43

BNIP3

1

1.19

3.97

4.25

ING

1

1.48

1.83

1.97

JUN

1

1.66

2.33

3.28

MAP2K1

1

1.38

2.16

2.05

TANK

1

1.77

1.34

1.60

BAX

1

2.45

0.88

1.44

IGFBP2

1

1.83

1.21

1.30

MDM2

1

4.75

1.44

2.47

TNFRSF6

1

5.70

0.69

5.11

CASP1

1

2.84

1.00

1.71

GAPD

1

1.13

1.43

1.68

K-ALPHA-1

1

1.03

0.78

0.73

RPS9

1

1.30

1.19

1.48

CDK7

1

1.60

1.60

1.52

NFKB1

1

1.27

1.40

1.25

BCL2A1

1

2.01

0.85

1.27

CDKN1C

1

1.45

1.06

0.90

CDKN2B

1

1.64

0.98

0.81

MAPK12

1

1.96

1.10

1.06

RBL2

1

1.88

1.03

0.99

RBP1

1

2.05

1.01

1.16

RIPK1

1

1.58

0.87

1.00

TP53

1

1.82

0.68

0.85

TP73

1

1.62

1.06

0.94

YWHAZ

1

2.62

0.82

0.81

BIRC5

1

1.07

0.68

0.66

CDC25C

1

2.17

0.60

0.59

CDK2

1

1.14

0.73

0.76

MAPK9

1

1.15

0.76

0.67

TFDP1

1

1.23

0.69

0.63

GSR

1

0.72

0.92

0.60

GSA

1

0.51

0.67

0.69

BID

1

1.50

0.83

1.06

BIK

1

2.09

0.63

0.92

CDK9

1

1.48

0.75

0.72

CLU

1

1.54

0.81

1.09

BclX

1

1.85

1.11

0.81

CASP2

1

1.12

0.83

0.81

CDK4

1

0.72

0.98

0.74

CDK5R1

1

1.43

0.87

0.75

CDK6

1

1.18

1.30

0.52

CSE1L

1

1.05

1.01

0.71

GRB2

1

1.31

0.83

0.72

IGF1R

1

1.26

1.10

0.66

LTB

1

1.38

0.97

0.82

PLK

1

1.14

0.81

0.46

TNFSF7

1

1.50

1.00

0.74

TRAF3

1

1.40

0.89

0.76

BAK 1

1

3.42

0.75

2.13

CDKN1A

1

3.02

0.52

1.64

GPX1

1

2.88

0.69

1.43

CDC2

1

3.22

0.74

0.83

PCNA

1

2.23

0.62

1.68

AKT2

1

1.55

1.00

0.78

E2F5

1

1.20

1.90

0.61

  1. Cells were incubated under normoxic (N) or hypoxic (H) conditions with or without etoposide (e, 50 μM) for 16 hours before RNA extraction, reverse-transcription and cDNA hybridization, as described in Materials and Methods. Each value is the average of three ratio values calculated from three independent experiments. Mean ratios indicate a fold-increase or decrease in gene expression.
  2. Value higher than 1 + 1 SD, Value lower than 1 - 1 SD
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Molecular Cancer

ISSN: 1476-4598