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Table 3 The table summarizes the effects of hypoxia and/or etoposide on the abundance and the activity of 10 transcription factors.

From: Hypoxia induces protection against etoposide-induced apoptosis: molecular profiling of changes in gene expression and transcription factor activity

    N Ne H He
p53   TFChipMAPK ++ +++ + ++
   Trans-AM ++ +++ + ++
   prot level ++ (cyt) +++ (cyt+nuc) + (cyt) ++ (cyt+nuc)
  P-p53 prot level (nuc) 0 +++ + +++
   reporter system ++ +++ + ++
AP-1 c-jun Trans-AM + + ++ +++
   prot level (nuc) + +++ ++ +++
  P-c-jun TFChipMAPK + + ++ +++
   prot level (nuc) + ++ + ++
  c-fos Trans-AM + +++ ++ +++
   prot level (cyt+nuc) + +++ ++ +++
   reporter system + + ++ +++
P-Elk-1   TFChipMAPK ++ ++ + ++
   Trans-AM ++ ++ + +
   prot level (nuc) + + + +
CREB/ATF2 P-ATF-2 TFChipMAPK ++ + ++ ++
   prot level (cyt+nuc) + + + ++
  P-CREB Trans-AM + + + +
   prot level (cyt+nuc) ++ ++ + +
   reporter system + + +++ +
MEF-2   TFChipMAPK ++ ++ + +
   prot level + (cyt+nuc) +++ (nuc) ++ (cyt+nuc) + (nuc)
c-myc   TFChipMAPK ++ 0 + 0
   Trans-AM +++ ++ + 0
   prot level (nuc) +++ + ++ +
   reporter system ++ 0 + 0
STAT-1   TFChipMAPK 0 0 0 +
   prot level + (cyt) + (cyt) + (cyt) +++ (cyt+nuc)
NFATc1   TFChipMAPK 0 0 0 0
NF-kB c-rel prot level (cyt+nuc) ++ ++ ++ ++
  p50 prot level (cyt+nuc) +++ ++ + ++
  p65 Trans-AM ++ +++ + +
   prot level (cyt) + + ++ +
   reporter system + ++ + ++
HIF-1 HIF-1α prot level (nuc) 0 0 ++ ++
   Trans-AM + + +++ +++
   reporter system + + +++ +++
  1. Cyt: cytosolic, nuc: nuclear, 0: not present or no activity.