Molecular Cancer

Table 3 The table summarizes the effects of hypoxia and/or etoposide on the abundance and the activity of 10 transcription factors.

From: Hypoxia induces protection against etoposide-induced apoptosis: molecular profiling of changes in gene expression and transcription factor activity

			N	Ne	H	He
p53		TFChipMAPK	++	+++	+	++
		Trans-AM	++	+++	+	++
		prot level	++ (cyt)	+++ (cyt+nuc)	+ (cyt)	++ (cyt+nuc)
	P-p53	prot level (nuc)	0	+++	+	+++
		reporter system	++	+++	+	++
AP-1	c-jun	Trans-AM	+	+	++	+++
		prot level (nuc)	+	+++	++	+++
	P-c-jun	TFChipMAPK	+	+	++	+++
		prot level (nuc)	+	++	+	++
	c-fos	Trans-AM	+	+++	++	+++
		prot level (cyt+nuc)	+	+++	++	+++
		reporter system	+	+	++	+++
P-Elk-1		TFChipMAPK	++	++	+	++
		Trans-AM	++	++	+	+
		prot level (nuc)	+	+	+	+
CREB/ATF2	P-ATF-2	TFChipMAPK	++	+	++	++
		prot level (cyt+nuc)	+	+	+	++
	P-CREB	Trans-AM	+	+	+	+
		prot level (cyt+nuc)	++	++	+	+
		reporter system	+	+	+++	+
MEF-2		TFChipMAPK	++	++	+	+
		prot level	+ (cyt+nuc)	+++ (nuc)	++ (cyt+nuc)	+ (nuc)
c-myc		TFChipMAPK	++	0	+	0
		Trans-AM	+++	++	+	0
		prot level (nuc)	+++	+	++	+
		reporter system	++	0	+	0
STAT-1		TFChipMAPK	0	0	0	+
		prot level	+ (cyt)	+ (cyt)	+ (cyt)	+++ (cyt+nuc)
NFATc1		TFChipMAPK	0	0	0	0
NF-kB	c-rel	prot level (cyt+nuc)	++	++	++	++
	p50	prot level (cyt+nuc)	+++	++	+	++
	p65	Trans-AM	++	+++	+	+
		prot level (cyt)	+	+	++	+
		reporter system	+	++	+	++
HIF-1	HIF-1α	prot level (nuc)	0	0	++	++
		Trans-AM	+	+	+++	+++
		reporter system	+	+	+++	+++

Cyt: cytosolic, nuc: nuclear, 0: not present or no activity.

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