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Figure 4 | Molecular Cancer

Figure 4

From: Myeloproliferative disorder FOP-FGFR1 fusion kinase recruits phosphoinositide-3 kinase and phospholipase Cγ at the centrosome

Figure 4

PI3K pathway is essential for FOP-FGFR1 expressing cell survival and proliferation. (A) LY294002 or rapamycin treatment abolishes FOP-FGFR1 effect on cell survival. Ba/F3 cells were washed free of IL3 and 1.106 cells were plated in triplicates in IL3 free medium, in the absence or presence of LY294002 10 μM, rapamycin 10 nM or equivalent amount of DMSO. Viable cells were counted over a 120 h-period. Results are means of three independent experiments. (B) The same survival experiment was done on Ba/F3 cells stably expressing either FOP-FGFR1 or its mutants.

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Molecular Cancer

ISSN: 1476-4598