Table 1 Summary of putative and potential functions of LASP-1 and LASP-2

LASP-1

focal contacts

signal transducer for IGF-1

[49]

zyxin recruiting protein

[38, 39]

modulator of migration and pseudopodial elongation

[19, 25, 38, 39, 46, 47]

interaction partner for cytoskeletal organisation

[7, 8, 10, 11, 13, 14, 26, 27]

stabilisation of actin filament bundles

[11]

modulator of active HCl secretion in gastric parietal cells

[17, 18, 20, 21, 70]

nucleus

modulator of proliferation in concert with other proteins

[25, 38, 39]

cell-cycle-control

[26, 38, 39]

(transcription factor)

[6, 25]

postsynaptic/CNS

axonal growth and differentiation/structural protein/autism linked gene

[40, 42]

Z-discs/A-bands

structural protein (possibly function in myofilament stabilization and assembly)

[12]

LASP-2

focal contacts

interaction partner for cytoskeletal organisation

[27, 30]

stabilisation of actin filament bundles

[11]

Z-discs

structural protein/myofilament stabilization and assembly

[12, 37]

CNS

unclear/structural protein

[30]