Figure 4
From: DNA-dependent protein kinase catalytic subunit modulates the stability of c-Myc oncoprotein
GSK3 plays a role in the regulation of DNA-PKcs on c-Myc. (A) Proteasome inhibitor MG132 recovered the downregulation of c-Myc in HeLa-H1 cells. (B) GSK3 isoforms inhibitor LiCl rescued the downregulated c-Myc in HeLa-H1 cells. (C) Phophorylation level of c-Myc (Thr58/Ser62) in HeLa-NC and HeLa-H1 cells, and the inhibiting effect of LiCl. (D) Depression of GSK3 α (upper panel) or GSK3 β (lower panel) by siRNA promotes c-Myc accumulation in HeLa-H1 cells.