Unsupervised hierarchical cluster heatmap based on differential miRNA expression patterns identified in the initial cohort. Vertical bars represent the samples and the horizontal bars represent the miRNA genes. Green bars reflect downregulated genes and red bars upregulated genes. Interestingly, P3 clusters with the recurrent samples on the left of the heatmap. P3 relapsed within 6 months post completion of treatment and should be considered "chemoresistant" P, primary tumours; R, recurrent tumors.